Drug Information
Drug General Information | Top | |||
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Drug ID |
D0N4HB
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Former ID |
DCL000716
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Drug Name |
Belatacept
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Synonyms |
Nulojix (TN); Belatacept (USAN/INN)
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Indication | Kidney transplant rejection [ICD-11: NE84; ICD-10: Z94.0; ICD-9: 996.81] | Approved | [1], [2] | |
Heart transplant rejection [ICD-11: NE84; ICD-9: 996] | NDA filed | [1], [3] | ||
Company |
Bristol-Myers Squibb
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PubChem Substance ID | ||||
ADReCS Drug ID | BADD_D00223 | |||
SuperDrug ATC ID |
L04AA28
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SuperDrug CAS ID |
cas=000086408
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Target and Pathway | Top | |||
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Target(s) | T-cell-specific surface glycoprotein CD28 (CD28) | Target Info | Inhibitor | [3] |
KEGG Pathway | Cell adhesion molecules (CAMs) | |||
T cell receptor signaling pathway | ||||
Intestinal immune network for IgA production | ||||
Type I diabetes mellitus | ||||
Measles | ||||
Autoimmune thyroid disease | ||||
Systemic lupus erythematosus | ||||
Rheumatoid arthritis | ||||
Allograft rejection | ||||
Graft-versus-host disease | ||||
Viral myocarditis | ||||
NetPath Pathway | TCR Signaling Pathway | |||
Panther Pathway | T cell activation | |||
Pathway Interaction Database | TCR signaling in naï | |||
TCR signaling in naï | ||||
IL12 signaling mediated by STAT4 | ||||
Reactome | PIP3 activates AKT signaling | |||
Constitutive Signaling by Aberrant PI3K in Cancer | ||||
CD28 co-stimulation | ||||
CD28 dependent PI3K/Akt signaling | ||||
CD28 dependent Vav1 pathway | ||||
WikiPathways | TCR Signaling Pathway | |||
Inflammatory Response Pathway | ||||
Host Interactions of HIV factors | ||||
PIP3 activates AKT signaling | ||||
T-Cell Receptor and Co-stimulatory Signaling | ||||
Allograft Rejection | ||||
Costimulation by the CD28 family |
References | Top | |||
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REF 1 | URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6892). | |||
REF 2 | 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4. | |||
REF 3 | New developments in immunosuppressive therapy for heart transplantation. Expert Opin Emerg Drugs. 2009 Mar;14(1):1-21. |
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