Target Validation Information
TTD ID	T85435
Target Name	Insulin receptor (INSR)
Type of Target	Successful
Drug Potency against Target	Insulin-detemir	Drug Info	Afinity = 5 nM	[4]
	4-((1H-indazol-6-ylamino)methyl)benzene-1,2-diol	Drug Info	IC50 = 2250 nM	[2]
	4-((naphthalen-2-ylamino)methyl)benzene-1,2-diol	Drug Info	IC50 = 5150 nM	[2]
	AEW-541	Drug Info	IC50 = 140 nM	[3]
	NVP-TAE684	Drug Info	IC50 = 1200 nM	[1]
References
REF 1	Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):270-5.
REF 2	ATP non-competitive IGF-1 receptor kinase inhibitors as lead anti-neoplastic and anti-papilloma agents. Eur J Pharmacol. 2007 May 7;562(1-2):1-11.
REF 3	Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach. J Med Chem. 2009 Aug 27;52(16):4981-5004.
REF 4	NPY Y1 and Y5 receptor selective antagonists as anti-obesity drugs. Curr Top Med Chem. 2007;7(17):1721-33.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.