| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T77664 | ||||
| Target Name | Interferon-gamma (IFNG) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | Fontolizumab | Drug Info | IC50 = 10 ug/ml | ||
| Action against Disease Model | Fontolizumab | Drug Info | Fontoliz uMab inhibited IFN-c-induced IP-10 production in a susceptible cell line, which can be nuetralized by anti-fontoliz uMab antibodies | [1] | |
| References | |||||
| REF 1 | Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's dis... Gut. 2006 Aug;55(8):1131-7. | ||||
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