| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T72835 | ||||
| Target Name | E-selectin (SELE) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | Bimosiamose | Drug Info | IC50 = 70 uMol/L | [1] | |
| Action against Disease Model | Bimosiamose | Drug Info | An sLex mimetic bimosiamose (TBC-1269) has an IC50 of 70 uMinan HL-60 cell binding assay to P-selectin. | [2] | |
| References | |||||
| REF 1 | Selectin antagonists : therapeutic potential in asthma and COPD. Treat Respir Med. 2005;4(2):85-94. | ||||
| REF 2 | Characterization of the novel P-selectin inhibitor PSI-697 [2-(4-chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[h] quinoline-4-carboxylic acid] i... J Pharmacol Exp Ther. 2008 Feb;324(2):497-506. | ||||
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