Target Validation Information
TTD ID	T70309
Target Name	Steroid 5-alpha-reductase 1 (SRD5A1)
Type of Target	Clinical trial
Drug Potency against Target	(3-methyl-4-(4-phenoxybenzoyl)phenyl)acetic acid	Drug Info	IC50 = 1450 nM	[5]
	1,2,5,6-tetrahydro pyrido[1,2-a]quinolin-3-one	Drug Info	IC50 = 298 nM	[4]
	1-Methyl-5-(4-phenylazo-phenyl)-piperidin-2-one	Drug Info	IC50 = 302 nM	[3]
	1-Methyl-5-phenyl-piperidin-2-one	Drug Info	IC50 = 2477 nM	[3]
	2,3,5,6-Tetrafluoro-4-pentafluorophenylazo-phenol	Drug Info	IC50 = 2000 nM	[6]
	3,4,5,6-Tetrahydrobenzo[c]quinolizin-3-(4aH)-one	Drug Info	IC50 = 5130 nM	[4]
	4,4'-dihydroxyoctafluoroazobenzene	Drug Info	IC50 = 790 nM	[6]
	4-Methyl-5,6-dihydro-pyrido[1,2-a]quinolin-3-one	Drug Info	IC50 = 1400 nM	[4]
	5-(4-Chloro-phenyl)-1-methyl-piperidin-2-one	Drug Info	IC50 = 1690 nM	[3]
	5-(4-Chloro-phenyl)-1-methyl-piperidine-2-thione	Drug Info	IC50 = 3360 nM	[3]
	Bexlosteride	Drug Info	IC50 = 8 nM	[2]
	FK-143	Drug Info	IC50 = 4.2 nM	[1]
	LY-266111	Drug Info	IC50 = 17 nM	[3]
	MK-386	Drug Info	IC50 = 0.5 nM	[2]
	ONO-3805	Drug Info	IC50 = 2.6 nM	[1]
References
REF 1	Dual-acting agents with alpha1-adrenoceptor antagonistic and steroid 5alpha-reductase inhibitory activities. Synthesis and evaluation of arylpipera... Bioorg Med Chem Lett. 1999 Jun 7;9(11):1553-8.
REF 2	Synthesis of 8-chloro-benzo[c]quinolizin-3-ones as potent and selective inhibitors of human steroid 5alpha-reductase 1. Bioorg Med Chem Lett. 2000 Feb 21;10(4):353-6.
REF 3	Simple bi- and tricyclic inhibitors of human steroid 5alpha-reductase. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1909-11.
REF 4	Benzo[c]quinolizin-3-ones: a novel class of potent and selective nonsteroidal inhibitors of human steroid 5alpha-reductase 1. J Med Chem. 2000 Oct 5;43(20):3718-35.
REF 5	Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59.
REF 6	Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis. J Med Chem. 1990 Sep;33(9):2452-5.

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