Target Validation Information | |||||
---|---|---|---|---|---|
TTD ID | T59190 | ||||
Target Name | Protein kinase C zeta (PRKCZ) | ||||
Type of Target |
Patented-recorded |
||||
Drug Potency against Target | Drug Info | IC50 = 3 nM | [2] | ||
LY-317644 | Drug Info | IC50 = 6400 nM | |||
LY-326449 | Drug Info | IC50 = 630 nM | [4] | ||
RO-316233 | Drug Info | IC50 = 550 nM | [3] | ||
Ro-32-0557 | Drug Info | IC50 = 6.8 nM | |||
RO-320432 | Drug Info | IC50 = 21 nM | |||
[2,2':5',2'']Terthiophen-4-yl-methanol | Drug Info | IC50 = 3000 nM | [1] | ||
[2,2':5',2'']Terthiophene-4,5''-dicarbaldehyde | Drug Info | IC50 = 700 nM | [1] | ||
[2,2':5',2'']Terthiophene-4-carbaldehyde | Drug Info | IC50 = 5000 nM | [1] | ||
References | |||||
REF 1 | Novel protein kinase C inhibitors: synthesis and PKC inhibition of beta-substituted polythiophene derivatives. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2279-82. | ||||
REF 2 | Mixed lineage kinase activity of indolocarbazole analogues. Bioorg Med Chem Lett. 2002 Jan 21;12(2):147-50. | ||||
REF 3 | Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84. | ||||
REF 4 | (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71. | ||||
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