Target Validation Information
TTD ID	T52953
Target Name	CRP messenger RNA (CRP mRNA)
Type of Target	Clinical trial
Action against Disease Model	ISIS-CRP	Drug Info	In preclinical studies,ISIS observed that their antisense inhibitor of CRP suppressed liver and ser uM CRP levels. However, there are serious concerns about the validation of the target: "On Wednesday's conference call ISIS's Stan in reference to ISIS-CRP said that "we could fairly dramatically affect the projection of cardiovascular lesions in these manipulated (animal) models." But he was also very clear where ISIS is headed with this drug as you can see from the following excerpt: "CRP is a well-known cause of inflammation and has been associated with cardiovascular and n uMerous other inflammatory diseases and conditions. It is also a very controversial target like cholesterol was in the 1960s". So two appropriate questions come to mind. First, why are we willingto risk R&D spending on such a controversial target? And second, how will we develop the drug to mitigate the risks associated with a non-validated target?"
References

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