| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T52188 | ||||
| Target Name | Plasmodium Acetyl-CoA carboxylase 1 (Malaria ACC1) | ||||
| Type of Target |
Literature-reported |
||||
| Drug Potency against Target | A-80040 | Drug Info | IC50 = 1000 nM | [1] | |
| CP-640186 | Drug Info | IC50 = 92 nM | [2] | ||
| References | |||||
| REF 1 | Synthesis and structure-activity relationships of N-{3-[2-(4-alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy derivatives as selective acet... J Med Chem. 2006 Jun 29;49(13):3770-3. | ||||
| REF 2 | Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2383-8. | ||||
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