| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T47623 | ||||
| Target Name | Heparanase (HPSE) | ||||
| Type of Target |
Successful |
||||
| Drug Potency against Target | PI-88 | Drug Info | Ki = 7.9 nM | [2] | |
| Action against Disease Model | PI-88 | Drug Info | PI-88 inhibit heparanase at Ki 8 nM. The IC50 values of PI-88 in growth factor-induced HUVEC proliferation assays are 20-30 uM. PI-88 at 10 |?M inhibits HUVEC tube formation by 29% | [1] | |
| References | |||||
| REF 1 | PI-88 and novel heparan sulfate mimetics inhibit angiogenesis. Semin Thromb Hemost. 2007 Jul;33(5):557-68. | ||||
| REF 2 | Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening. Anal Biochem. 2010 Jan 1;396(1):112-6. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.