Target Validation Information
TTD ID	T41666
Target Name	Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ)
Type of Target	Patented-recorded
Drug Potency against Target	9-[2-(1-Phosphonobutan-2-yloxy)ethyl]guanine	Drug Info	Ki = 300 nM	[1]
	9-[2-(1-Phosphonobutan-2-yloxy)ethyl]hypoxanthine	Drug Info	Ki = 10000 nM	[1]
	9-[2-(1-Phosphonopropan-2-yloxy)ethyl]guanine	Drug Info	Ki = 100 nM	[1]
References
REF 1	Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum h... Bioorg Med Chem. 2009 Sep 1;17(17):6218-32.

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