Target Information
| Target General Information | Top | |||||
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| Target ID |
T41666
(Former ID: TTDR00219)
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| Target Name |
Plasmodium Hypoxanthine-guanine phosphoribosyltransferase (Malaria LACZ)
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| Synonyms |
LACZ of Plasmodium falciparum (isolate FCR-3 / Gambia); Hypoxanthine phosphoribosyltransferase; HPRT; HGPRTase; HGPRT of Plasmodium falciparum (isolate FCR-3 / Gambia); Guanine phosphoribosyltransferase; GPRT
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| Gene Name |
Malaria LACZ
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| Target Type |
Patented-recorded target
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| Function |
Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
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| BioChemical Class |
Pentosyltransferase
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| UniProt ID | ||||||
| Sequence |
MPIPNNPGAGENAFDPVFVNDDDGYDLDSFMIPAHYKKYLTKVLVPNGVIKNRIEKLAYD
IKKVYNNEEFHILCLLKGSRGFFTALLKHLSRIHNYSAVETSKPLFGEHYVRVKSYCNDQ STGTLEIVSEDLSCLKGKHVLIVEDIIDTGKTLVKFCEYLKKFEIKTVAIACLFIKRTPL WNGFKADFVGFSIPDHFVVGYSLDYNEIFRDLDHCCLVNDEGKKKYKATSL Click to Show/Hide
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| 3D Structure | Click to Show 3D Structure of This Target | PDB | ||||
| Drug Binding Sites of Target | Top | |||||
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| Ligand Name: Hypoxanthine | Ligand Info | |||||
| Structure Description | Crystal Structure of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase in complex with hypoxanthine | PDB:3OZF | ||||
| Method | X-ray diffraction | Resolution | 1.94 Å | Mutation | No | [6] |
| PDB Sequence |
PRGSHMPIPN
5 NPGAGENAFD15 PVFVNDDDGY25 DLDSFMIPAH35 YKKYLTKVLV45 PNGVIKNRIE 55 KLAYDIKKVY65 NNEEFHILCL75 LKGSRGFFTA85 LLKHLSRIHN95 YSAVETSKPL 105 FGEHYVRVKS115 YCNDQSTGTL125 EIVSEDLSCL135 KGKHVLIVED145 IIDTGKTLVK 155 FCEYLKKFEI165 KTVAIACLFI175 KRTPLWNGFK185 ADFVGFSIPD195 HFVVGYSLDY 205 NEIFRDLDHC215 CLVNDEGKKK225 YKA
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| Ligand Name: Pyrophosphate 2- | Ligand Info | |||||
| Structure Description | Crystal Structure of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase in complex with hypoxanthine | PDB:3OZF | ||||
| Method | X-ray diffraction | Resolution | 1.94 Å | Mutation | No | [6] |
| PDB Sequence |
PRGSHMPIPN
5 NPGAGENAFD15 PVFVNDDDGY25 DLDSFMIPAH35 YKKYLTKVLV45 PNGVIKNRIE 55 KLAYDIKKVY65 NNEEFHILCL75 LKGSRGFFTA85 LLKHLSRIHN95 YSAVETSKPL 105 FGEHYVRVKS115 YCNDQSTGTL125 EIVSEDLSCL135 KGKHVLIVED145 IIDTGKTLVK 155 FCEYLKKFEI165 KTVAIACLFI175 KRTPLWNGFK185 ADFVGFSIPD195 HFVVGYSLDY 205 NEIFRDLDHC215 CLVNDEGKKK225 YKA
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| Click to View More Binding Site Information of This Target and Ligand Pair | ||||||
| Click to View More Binding Site Information of This Target with Different Ligands | ||||||
| Different Human System Profiles of Target | Top |
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Human Similarity Proteins
of target is determined by comparing the sequence similarity of all human proteins with the target based on BLAST. The similarity proteins for a target are defined as the proteins with E-value < 0.005 and outside the protein families of the target.
A target that has fewer human similarity proteins outside its family is commonly regarded to possess a greater capacity to avoid undesired interactions and thus increase the possibility of finding successful drugs
(Brief Bioinform, 21: 649-662, 2020).
Human Similarity Proteins
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There is no similarity protein (E value < 0.005) for this target
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| Drug Property Profile of Target | Top | |
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| (1) Molecular Weight (mw) based Drug Clustering | (2) Octanol/Water Partition Coefficient (xlogp) based Drug Clustering | |
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| (3) Hydrogen Bond Donor Count (hbonddonor) based Drug Clustering | (4) Hydrogen Bond Acceptor Count (hbondacc) based Drug Clustering | |
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| (5) Rotatable Bond Count (rotbonds) based Drug Clustering | (6) Topological Polar Surface Area (polararea) based Drug Clustering | |
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| "RO5" indicates the cutoff set by lipinski's rule of five; "D123AB" colored in GREEN denotes the no violation of any cutoff in lipinski's rule of five; "D123AB" colored in PURPLE refers to the violation of only one cutoff in lipinski's rule of five; "D123AB" colored in BLACK represents the violation of more than one cutoffs in lipinski's rule of five | ||
| Target Affiliated Biological Pathways | Top | |||||
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| KEGG Pathway | [+] 3 KEGG Pathways | + | ||||
| 1 | Purine metabolism | |||||
| 2 | Drug metabolism - other enzymes | |||||
| 3 | Metabolic pathways | |||||
| Pathwhiz Pathway | [+] 1 Pathwhiz Pathways | + | ||||
| 1 | Purine Metabolism | |||||
| Reactome | [+] 1 Reactome Pathways | + | ||||
| 1 | Purine salvage | |||||
| WikiPathways | [+] 4 WikiPathways | + | ||||
| 1 | Nucleotide Metabolism | |||||
| 2 | Mesodermal Commitment Pathway | |||||
| 3 | Endoderm Differentiation | |||||
| 4 | Metabolism of nucleotides | |||||
| Target-Related Models and Studies | Top | |||||
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| Target Validation | ||||||
| References | Top | |||||
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| REF 1 | How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | |||||
| REF 2 | 6-oxopurine phosphoribosyltransferase inhibitors. US9200020. | |||||
| REF 3 | DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41. | |||||
| REF 4 | Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum h... Bioorg Med Chem. 2009 Sep 1;17(17):6218-32. | |||||
| REF 5 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. | |||||
| REF 6 | Acyclic immucillin phosphonates: second-generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase. Chem Biol. 2012 Jun 22;19(6):721-30. | |||||
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