Target Validation Information
TTD ID	T40492
Target Name	Hepatitis C virus NS3 helicase (HCV NS3)
Type of Target	Successful
Drug Potency against Target	2,4,6-Trihydroxy-3-nitro-N-tridecyl-benzamide	Drug Info	IC50 = 5800 nM	[2]
	Ac-Glu-Cha-Cys	Drug Info	Ki = 4100 nM	[1]
	AcAsp-D-Gla-Leu-Ile-Cha-Cys	Drug Info	Ki = 0.75 nM	[2]
	AcAsp-Gla-Leu-Ile-Cha-Cys	Drug Info	Ki = 0.75 nM	[1]
	AcAsp-Glu-Cha-Val-Prb-Cpg	Drug Info	IC50 = 51 nM	[2]
	AcAsp-Glu-Cha-Val-Prb-Cys	Drug Info	IC50 = 33 nM	[2]
	AcAsp-Glu-Dif-Glu-Cha-Cys	Drug Info	Ki = 40 nM	[2]
	AcAsp-Glu-Dif-Glu-Cha-Fab	Drug Info	Ki = 10 nM	[2]
	AcAsp-Glu-Dif-Ile-Cha-Cys	Drug Info	Ki = 30 nM	[1]
	AcAsp-Glu-Dif-Ile-Cha-Cys-Iqc-Nle-Thr-TyrNH2	Drug Info	IC50 = 100 nM	[2]
	AcAsp-Glu-Dif-Ile-Cha-Cys-Pro-Cha-Asp-ValNH2	Drug Info	IC50 = 1300 nM	[2]
	AcAsp-Glu-Dif-Ile-Cha-Cys-Pro-Nle-Asp-ValNH2	Drug Info	IC50 = 1800 nM	[2]
	AcAsp-Glu-Dif-Lys-Cha-Cys	Drug Info	Ki = 1240 nM	[1]
	AcAsp-Glu-Met-Glu-Cha-Cys	Drug Info	Ki = 400 nM	[1]
	AcAsp-Glu-Met-Glu-Glu-Cys	Drug Info	Ki = 600 nM	[2]
	AcAsp-Glu-Met-Glu-Nal-Cyse	Drug Info	Ki = 180 nM	[1]
	AcDif-Glu-Cha-Cys	Drug Info	Ki = 15000 nM	[1]
	AcDif-Ile-Cha-Cys	Drug Info	Ki = 2100 nM	[1]
	AcGlu-Asp-Val-Val-Leu-Cys-Iqc-Nle-Thr-TyrNH2	Drug Info	IC50 = 1000 nM	[2]
	AcGlu-Dif-Glu-Cha-Cys	Drug Info	Ki = 700 nM	[1]
	AcGlu-Dif-Ile-Cha-Cys	Drug Info	Ki = 1200 nM	[1]
	Asp-D-Glu-Leu-Glu-Cha-Cys	Drug Info	Ki = 1540 nM	[1]
	Boc-Ile-Leu-L-(difluoro)aminobutyric aid	Drug Info	IC50 = 1000 nM	[2]
	Cbz-Ile-Leu-L-(difluoro)aminobutyric acid	Drug Info	IC50 = 1700 nM	[2]
	GNF-PF-3464	Drug Info	IC50 = 7092 nM	[3]
	PATULIN	Drug Info	IC50 = 3800 nM	[2]
	SCH-68631	Drug Info	IC50 = 7000 nM	[2]
References
REF 1	Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain. Bioorg Med Chem Lett. 2001 Jan 22;11(2):203-6.
REF 2	Control of hepatitis C: a medicinal chemistry perspective. J Med Chem. 2005 Jan 13;48(1):1-20.
REF 3	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.

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