Drug Information
| Drug General Information | Top | |||
|---|---|---|---|---|
| Drug ID |
D00PVO
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| Former ID |
DNC011360
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| Drug Name |
GNF-PF-3464
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| Synonyms |
GNF-Pf-3464; MLS000080647; SMR000035446; 3-(4-bromophenyl)-8-(5-methylfuran-2-yl)-6-oxo-2,4,7,8-tetrahydropyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile; AC1LDF42; MLS002584786; cid_666034; CHEMBL602213; BDBM54721; MolPort-002-638-170; HMS2390G20; CCG-29223; STK849599; AKOS001814539; AKOS022041133; MCULE-2552432292; SR-01000096914; SR-01000096914-1; 3-(4-bromophenyl)-8-(5-methylfuran-2-yl)-6-oxo-3,4,7,8-tetrahydro-2H,6H-pyrido[2,1-b][1,3,5]thiadiazine-9-carbonitrile
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent [ICD-11: N.A.] | Investigative | [1] | |
| Structure |
 |
Download2D MOL |
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| Formula |
C19H16BrN3O2S
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| Canonical SMILES |
CC1=CC=C(O1)C2CC(=O)N3CN(CSC3=C2C#N)C4=CC=C(C=C4)Br
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| InChI |
1S/C19H16BrN3O2S/c1-12-2-7-17(25-12)15-8-18(24)23-10-22(11-26-19(23)16(15)9-21)14-5-3-13(20)4-6-14/h2-7,15H,8,10-11H2,1H3
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| InChIKey |
DCNZODDMKOTPHQ-UHFFFAOYSA-N
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| PubChem Compound ID | ||||
| Target and Pathway | Top | |||
|---|---|---|---|---|
| Target(s) | Hepatitis C virus NS3 helicase (HCV NS3) | Target Info | Inhibitor | [1] |
| Voltage-gated calcium channel alpha Cav2.2 (CACNA1B) | Target Info | Inhibitor | [1] | |
| KEGG Pathway | MAPK signaling pathway | |||
| Calcium signaling pathway | ||||
| Synaptic vesicle cycle | ||||
| Retrograde endocannabinoid signaling | ||||
| Cholinergic synapse | ||||
| Serotonergic synapse | ||||
| GABAergic synapse | ||||
| Dopaminergic synapse | ||||
| Taste transduction | ||||
| Type II diabetes mellitus | ||||
| Morphine addiction | ||||
| Nicotine addiction | ||||
| Panther Pathway | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | |||
| Ionotropic glutamate receptor pathway | ||||
| Metabotropic glutamate receptor group III pathway | ||||
| Metabotropic glutamate receptor group II pathway | ||||
| Thyrotropin-releasing hormone receptor signaling pathway | ||||
| Endogenous cannabinoid signaling | ||||
| GABA-B receptor II signaling | ||||
| Reactome | Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels | |||
| WikiPathways | Calcium Regulation in the Cardiac Cell | |||
| Synaptic Vesicle Pathway | ||||
| References | Top | |||
|---|---|---|---|---|
| REF 1 | In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. | |||
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