| Target Validation Information | |||||
|---|---|---|---|---|---|
| TTD ID | T22655 | ||||
| Target Name | Mucosal addressin cell adhesion molecule 1 (MADCAM1) | ||||
| Type of Target |
Clinical trial |
||||
| Drug Potency against Target | SCH-527123 | Drug Info | IC50 = 37 ng/mL | [1] | |
| Action against Disease Model | SCH-527123 | Drug Info | MECA-367 and PF-00547659 (an anti-h uMan MAdCAM monoclonal antibody) bound with high affinity to mouse and h uMan MAdCAM with K(d) values of 5.1 and 16.1 pmol.L(-1) respectivelyand blocked the adhesion of alpha(4)beta(7) (+) leukocytes to MAdCAM with similar potency. MECA-367 and PF-00547659 induced a similar, dose-dependent two- to threefold increase in circulating populations of beta(7) (+) memory T-cells in the mouse and macaque; without affecting the beta(7) (-) populations. | [1] | |
| References | |||||
| REF 1 | Pharmacological characterization of PF-00547659, an anti-human MAdCAM monoclonal antibody. Br J Pharmacol. 2009 May;157(2):281-93. | ||||
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