Target Validation Information
TTD ID	T19160
Target Name	Group IIA phospholipase A2 (GIIA sPLA2)
Type of Target	Clinical trial
Drug Potency against Target	2-(4-phenoxyphenoxy)ethanamine	Drug Info	IC50 = 7300 nM	[4]
	BOLINAQUINONE	Drug Info	IC50 = 200 nM	[1]
	CACOSPONGIONOLIDE	Drug Info	IC50 = 3000 nM	[5]
	DIDODECANOYLPHLOROGLUCINOL	Drug Info	IC50 = 10 nM	[3]
	DYSIDINE	Drug Info	IC50 = 2000 nM	[1]
	MANOALIDE	Drug Info	IC50 = 3900 nM	[5]
	Ochnaflavone	Drug Info	IC50 = 3500 nM	[2]
	YM-26734	Drug Info	IC50 = 85 nM	[3]
References
REF 1	New sesquiterpene derivatives from the sponge Dysidea species with a selective inhibitor profile against human phospholipase A2 and other leukocyte... J Nat Prod. 2001 May;64(5):612-5.
REF 2	Synthesis of phospholipase A2 inhibitory biflavonoids. Bioorg Med Chem Lett. 2006 May 1;16(9):2373-5.
REF 3	Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5415-9.
REF 4	Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching. J Med Chem. 2008 Dec 25;51(24):7882-8.
REF 5	A new cacospongionolide inhibitor of human secretory phospholipase A2 from the Tyrrhenian sponge Fasciospongia cavernosa and absolute configuration... J Nat Prod. 1998 Jul;61(7):931-5.

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