Target Validation Information
TTD ID	T00663
Target Name	Stress-activated protein kinase JNK3 (JNK3)
Type of Target	Patented-recorded
Drug Potency against Target	AS-601245	Drug Info	IC50 = 70 nM	[3]
	N-(4-amino-5-cyano-6-ethoxypyridin-2-yl)acetamide	Drug Info	Ki = 520 nM	[2]
	N-(4-amino-5-cyano-6-phenylpyridin-2-yl)acetamide	Drug Info	Ki = 3300 nM	[2]
	Phenyl-(3-phenyl-1H-indazol-6-yl)-amine	Drug Info	IC50 = 48 nM	[1]
References
REF 1	Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5095-9.
REF 2	Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80.
REF 3	A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8.

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