Target Interacting Protein Information
Target General Information | Top | ||||
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Target ID | T99954 | Target Info | |||
Target Name | Prostacyclin receptor (PTGIR) | ||||
Synonyms | Prostanoid IP receptor; Prostaglandin I2 receptor; PRIPR; PGI2 receptor; PGI receptor; IP prostanoid receptor | ||||
Target Type | Successful Target | ||||
Gene Name | PTGIR | ||||
Biochemical Class | GPCR rhodopsin | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
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Acid anhydride hydrolases | [+] 1 Acid anhydride hydrolases | + | |||
Interacting Protein Name | Ras-related protein Rab-11A (RAB11A) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | YL8 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [1] | |||
2 | Affinity Capture-Western | [2] | |||
3 | Yeast two hybrid | [1] | |||
4 | Yeast two hybrid | [3] | |||
G-protein-coupled receptors | [+] 1 G-protein-coupled receptors | + | |||
Interacting Target Name | Thromboxane A2 receptor (TBXA2R) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | TXA2-R; TXA2 receptor; Prostanoid TP receptor | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [4] | |||
2 | Fluorescence Resonance Energy Transfer | [5] | |||
Other proteins | [+] 1 Other proteins | + | |||
Interacting Protein Name | Neuroendocrine secretory protein 55 (GNAS) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | AHO; C20orf45; GNAS1; GPSA; GSA; GSP; NESP; PHP1A; PHP1B; PHP1C; POH | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [6] | |||
2 | Co-crystal Structure | [7] | |||
3 | Fluorescence Resonance Energy Transfer | [8] | |||
4 | Reconstituted Complex | [9] |
References | Top | ||||
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REF 1 | Recycling of the human prostacyclin receptor is regulated through a direct interaction with Rab11a GTPase. Cell Signal. 2008 Dec;20(12):2332-46. | ||||
REF 2 | Interaction of the human prostacyclin receptor with Rab11: characterization of a novel Rab11 binding domain within alpha-helix 8 that is regulated by palmitoylation. J Biol Chem. 2010 Jun 11;285(24):18709-26. | ||||
REF 3 | Interaction of the human prostacyclin receptor with the PDZ adapter protein PDZK1: role in endothelial cell migration and angiogenesis. Mol Biol Cell. 2011 Aug 1;22(15):2664-79. | ||||
REF 4 | Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation. J Biol Chem. 2004 Dec 17;279(51):53036-47. | ||||
REF 5 | Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease. Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1802-9. | ||||
REF 6 | Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor. Eur J Biochem. 2002 Mar;269(6):1714-25. | ||||
REF 7 | Solution structure of the first intracellular loop of prostacyclin receptor and implication of its interaction with the C-terminal segment of G alpha s protein. Biochemistry. 2006 Feb 14;45(6):1734-44. | ||||
REF 8 | Heterotrimeric G proteins precouple with G protein-coupled receptors in living cells. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18706-11. | ||||
REF 9 | A profile of the residues in the first intracellular loop critical for Gs-mediated signaling of human prostacyclin receptor characterized by an integrative approach of NMR-experiment and mutagenesis. Biochemistry. 2005 Aug 30;44(34):11389-401. |
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