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| Target General Information |
Top |
| Target ID |
T99397 |
Target Info
|
| Target Name |
Voltage-dependent anion-selective channel 1 (VDAC1) |
| Synonyms |
Porin 31HM; Porin 31HL; Plasmalemmal porin; Outer mitochondrial membrane protein porin 1 |
| Target Type |
Clinical trial Target |
| Gene Name |
VDAC1 |
| Biochemical Class |
Eukaryotic mitochondrial porin |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Alpha-type channels |
[+] 1 Alpha-type channels |
+ |
| Interacting Target Name |
Apoptosis regulator Bcl-xL (BCL-xL) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Bcl-XL; BCLX; Bcl-2-like protein 1; Bcl2like protein 1; Bcl2-L-1; Bcl2L1; BCL2L; Apoptosis regulator Bcl-X |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Reconstituted Complex |
[2] |
| References |
Top |
| REF 1 |
Direct control of mitochondrial function by mTOR. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22229-32.
|
| REF 2 |
Specific cleavage of Mcl-1 by caspase-3 in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in Jurkat leukemia T cells. J Biol Chem. 2005 Mar 18;280(11):10491-500.
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