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| Target General Information |
Top |
| Target ID |
T99204 |
Target Info
|
| Target Name |
Presenilin 2 (PSEN2) |
| Synonyms |
STM2; STM-2; Presenilin-2; PSNL2; PS-2; E5-1; AD5; AD4; AD3LP |
| Target Type |
Clinical trial Target |
| Gene Name |
PSEN2 |
| Biochemical Class |
Peptidase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Auxiliary transporters |
[+] 1 Auxiliary transporters |
+ |
| Interacting Protein Name |
Calsenilin (KCNIP3) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
CSEN; DREAM; KCHIP3 |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Yeast two hybrid |
[2] |
| Peptidases |
[+] 1 Peptidases |
+ |
| Interacting Target Name |
Presenilin 1 (PSEN1) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
S182 protein; PSNL1; PS-1; PS1; Protein S182; Presenilin-1; AD3 |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[3] |
| 2 |
Yeast two hybrid |
[4] |
| References |
Top |
| REF 1 |
Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2. J Biol Chem. 2001 Jun 1;276(22):19197-204.
|
| REF 2 |
Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat Med. 1998 Oct;4(10):1177-81.
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| REF 3 |
APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes. J Biol Chem. 2003 Feb 28;278(9):7374-80.
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| REF 4 |
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease. Genome Res. 2011 Mar;21(3):364-76.
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