Content Navigation
( All
None )
| Target General Information |
Top |
| Target ID |
T96301 |
Target Info
|
| Target Name |
DEP domain-containing protein 6 (DEPTOR) |
| Synonyms |
DEPDC6 |
| Target Type |
Literature-reported Target |
| Gene Name |
DEPTOR |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
Serine/threonine-protein kinase mTOR (mTOR) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
TOR kinase; Target of rapamycin; RAPT1; Rapamycin target protein 1; Rapamycin target protein; Rapamycin and FKBP12 target 1; RAFT1; Mechanistic target of rapamycin; Mammalian target of rapamycin; FRAP2; FRAP1; FRAP; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein; FK506-binding protein 12-rapamycin complex-associated protein 1 |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Biochemical Activity |
[2] |
| References |
Top |
| REF 1 |
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell. 2009 May 29;137(5):873-86.
|
| REF 2 |
mTOR generates an auto-amplification loop by triggering the TrCP- and CK1-dependent degradation of DEPTOR. Mol Cell. 2011 Oct 21;44(2):317-24.
|
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.
