Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T93995 Target Info
Target Name Ubiquitin-like protein Nedd8 (NEDD8)
Synonyms Neural precursor cell expressed developmentally down-regulated protein 8; Neddylin; NEDD-8
Target Type Clinical trial Target
Gene Name NEDD8
Biochemical Class Ubiquitin family
UniProt ID
NEDD8_HUMAN 
Target Interacting Proteins  Top
Peptidases [+] 2 Peptidases +
Interacting Target Name Deneddylase-1 (SENP8) Literature-reported Target Interacting Protein Info
UniProt ID
SENP8_HUMAN 
Synonyms Sentrin-specific protease 8; Sentrin/SUMO-specific protease SENP8; PRSC2; Protease, cysteine 2; NEDP1; NEDD8-specific protease 1; FKSG8; DEN1
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [1]
2 Co-crystal Structure [2]
3 Reconstituted Complex [3]
Interacting Target Name JUN activation domain binding protein (COPS5) Literature-reported Target Interacting Protein Info
UniProt ID
CSN5_HUMAN 
Synonyms Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Reconstituted Complex [5]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-crystal Structure [7]
3 Reconstituted Complex [7]
References  Top
REF 1 A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity. Anal Biochem. 2009 Jul 1;390(1):85-7.
REF 2 Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J. 2005 Apr 6;24(7):1341-51.
REF 3 DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. J Biol Chem. 2003 Aug 1;278(31):28882-91.
REF 4 Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.
REF 5 Structural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimer. PLoS One. 2014 Aug 21;9(8):e105688.
REF 6 Large-scale analysis of the human ubiquitin-related proteome. Proteomics. 2005 Nov;5(16):4145-51.
REF 7 Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system. Mol Cell Proteomics. 2012 Dec;11(12):1595-611.

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