Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T88322 Target Info
Target Name Facilitates chromatin transcription complex (FACT)
Synonyms hSSRP1; T160; Structure-specific recognition protein 1; Recombination signal sequence recognition protein 1; Facilitates chromatin transcription complex subunit SSRP1; Facilitates chromatin transcription complex 80 kDa subunit; FACTp80; FACT80; FACT complex subunit SSRP1; FACT 80 kDa subunit; Chromatin-specific transcription elongation factor 80 kDa subunit
Target Type Clinical trial Target
Gene Name SSRP1
UniProt ID
SSRP1_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 6 Acid anhydride hydrolases +
Interacting Target Name DNA replication licensing factor MCM6 (MCM6) Literature-reported Target Interacting Protein Info
UniProt ID
MCM6_HUMAN 
Synonyms p105MCM; Minichromosome maintenanceprotein 6
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
Interacting Target Name DNA replication licensing factor MCM7 (MCM7) Literature-reported Target Interacting Protein Info
UniProt ID
MCM7_HUMAN 
Synonyms P1.1-MCM3; Minichromosome maintenanceprotein 7; MCM2; CDC47 homolog; CDC47
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
Interacting Protein Name DNA replication licensing factor MCM2 (MCM2) Interacting Protein Interacting Protein Info
UniProt ID
MCM2_HUMAN 
Synonyms BM28; CCNL1; CDCL1; D3S3194; MITOTIN; cdc19
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
Interacting Protein Name DNA replication licensing factor MCM4 (MCM4) Interacting Protein Interacting Protein Info
UniProt ID
MCM4_HUMAN 
Synonyms CDC21; CDC54; NKCD; NKGCD; P1.CDC21; hCdc21
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
Interacting Protein Name DNA replication licensing factor MCM3 (MCM3) Interacting Protein Interacting Protein Info
UniProt ID
MCM3_HUMAN 
Synonyms HCC5; P1.MCM3; P1.h; RLFB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
Interacting Protein Name DNA replication licensing factor MCM5 (MCM5) Interacting Protein Interacting Protein Info
UniProt ID
MCM5_HUMAN 
Synonyms CDC46; P1.CDC46
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
Histones [+] 1 Histones +
Interacting Target Name Gamma-Histone H2AX (H2AFX) Literature-reported Target Interacting Protein Info
UniProt ID
H2AX_HUMAN 
Synonyms Phosphorylation of H2AX; Histone H2AX; Histone H2A.x; H2AX; H2a/x
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Reconstituted Complex [5]
Kinases [+] 2 Kinases +
Interacting Target Name Casein kinase II alpha (CSNK2A1) Clinical trial Target Interacting Protein Info
UniProt ID
CSK21_HUMAN 
Synonyms Protein kinase CK2; CK2A1; CK II alpha; CK II; Casein kinase II subunit alpha
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Biochemical Activity [7]
3 Co-fractionation [8]
Interacting Protein Name Serine/threonine-protein kinase Nek9 (NEK9) Interacting Protein Interacting Protein Info
UniProt ID
NEK9_HUMAN 
Synonyms NERCC; NERCC1; Nek8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [3]
Peptidases [+] 1 Peptidases +
Interacting Protein Name FACT complex subunit SPT16 (SUPT16H) Interacting Protein Interacting Protein Info
UniProt ID
SP16H_HUMAN 
Synonyms CDC68; FACTP140; SPT16/CDC68
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [10]
4 Affinity Capture-Western [3]
5 Affinity Capture-Western [11]
6 Affinity Capture-Western [12]
7 Co-fractionation [13]
Other proteins [+] 2 Other proteins +
Interacting Protein Name Tonsoku-like protein (TONSL) Interacting Protein Interacting Protein Info
UniProt ID
TONSL_HUMAN 
Synonyms IKBR; NFKBIL2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Co-localization [14]
Interacting Protein Name Protein MMS22-like (MMS22L) Interacting Protein Interacting Protein Info
UniProt ID
MMS22_HUMAN 
Synonyms C6orf167; dJ39B17.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
References  Top
REF 1 A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell. 2010 Nov 24;40(4):645-57.
REF 2 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 3 Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication. EMBO J. 2006 Sep 6;25(17):3975-85.
REF 4 The dynamic alterations of H2AX complex during DNA repair detected by a proteomic approach reveal the critical roles of Ca(2+)/calmodulin in the ionizing radiation-induced cell cycle arrest. Mol Cell Proteomics. 2006 Jun;5(6):1033-44.
REF 5 FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell. 2008 Apr 11;30(1):86-97.
REF 6 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Sci Signal. 2015 Apr 7;8(371):rs3.
REF 7 A bead-based approach for large-scale identification of in vitro kinase substrates. Proteomics. 2011 Dec;11(24):4632-7.
REF 8 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 9 Nek9, a novel FACT-associated protein, modulates interphase progression. J Biol Chem. 2004 Mar 5;279(10):9321-30.
REF 10 FACT facilitates chromatin transcription by RNA polymerases I and III. EMBO J. 2009 Apr 8;28(7):854-65.
REF 11 Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell. 2006 May 19;125(4):703-17.
REF 12 Modulation of nucleosome-binding activity of FACT by poly(ADP-ribosyl)ation. Nucleic Acids Res. 2006 May 8;34(8):2398-407.
REF 13 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 14 Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Genes Dev. 2014 Sep 1;28(17):1957-75.

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