Target Interacting Protein Information
Target General Information | Top | ||||
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Target ID | T86591 | Target Info | |||
Target Name | Peroxisome proliferator-activated receptor alpha (PPARA) | ||||
Synonyms | Peroxisome proliferater-activated receptor alpha; PPARalpha; PPAR-alpha; PPAR; Nuclear receptor subfamily 1 group C member 1; NR1C1 | ||||
Target Type | Successful Target | ||||
Gene Name | PPARA | ||||
Biochemical Class | Nuclear hormone receptor | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
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Acyltransferases | [+] 2 Acyltransferases | + | |||
Interacting Target Name | Histone acetyltransferase p300 (EP300) | Clinical trial Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Reconstituted Complex | [1] | |||
2 | Yeast two hybrid | [2] | |||
3 | Yeast two hybrid | [1] | |||
4 | Yeast two hybrid | [3] | |||
Interacting Protein Name | Nuclear receptor coactivator 1 (NCOA1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Fluorescence Resonance Energy Transfer | [4] | |||
2 | Reconstituted Complex | [5] | |||
3 | Reconstituted Complex | [6] | |||
4 | Yeast two hybrid | [2] | |||
Nuclear hormone receptors | [+] 1 Nuclear hormone receptors | + | |||
Interacting Target Name | Retinoic acid receptor RXR-alpha (RXRA) | Successful Target | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | RXRalpha; Retinoid X receptor alpha; Nuclear receptor subfamily 2 group B member 1; NR2B1 | ||||
Evidence Score (E-score) | 4 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [7] | |||
2 | Reconstituted Complex | [8] | |||
3 | Reconstituted Complex | [6] | |||
4 | Reconstituted Complex | [9] | |||
Transcription regulators | [+] 2 Transcription regulators | + | |||
Interacting Protein Name | Nuclear receptor corepressor 1 (NCOR1) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR | ||||
Evidence Score (E-score) | 3 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [10] | |||
2 | Reconstituted Complex | [1] | |||
3 | Yeast two hybrid | [1] | |||
Interacting Protein Name | Nuclear receptor corepressor 2 (NCOR2) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | CTG26; N.CoR2; SMAP270; SMRT; SMRTE; SMRTE.tau; TNRC14; TRAC; TRAC.1; TRAC1 | ||||
Evidence Score (E-score) | 2 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [10] | |||
2 | Co-crystal Structure | [11] |
References | Top | ||||
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REF 1 | Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein. J Biol Chem. 1999 May 28;274(22):15901-7. | ||||
REF 2 | p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha. J Biol Chem. 1997 Dec 26;272(52):33435-43. | ||||
REF 3 | PPAR alpha and PPAR delta transactivity and p300 binding activity induced by arachidonic acid in colorectal cancer cell line Caco-2. J Nutr Sci Vitaminol (Tokyo). 2008 Aug;54(4):298-302. | ||||
REF 4 | Ligand and coactivator recruitment preferences of peroxisome proliferator activated receptor alpha. J Steroid Biochem Mol Biol. 2002 Jul;81(3):217-25. | ||||
REF 5 | A regulatory role for RIP140 in nuclear receptor activation. Mol Endocrinol. 1998 Jun;12(6):864-81. | ||||
REF 6 | Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators. J Biol Chem. 2005 Jul 15;280(28):26543-56. | ||||
REF 7 | Peroxisome proliferator-activated receptors modulate proliferation and angiogenesis in human endometrial carcinoma. Mol Cancer Res. 2012 Mar;10(3):441-53. | ||||
REF 8 | Conserved amino acids in the ligand-binding and tau(i) domains of the peroxisome proliferator-activated receptor alpha are necessary for heterodimerization with RXR. Mol Cell Endocrinol. 1999 Jan 25;147(1-2):37-47. | ||||
REF 9 | Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element. J Lipid Res. 2003 Apr;44(4):686-95. | ||||
REF 10 | SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR. J Biol Chem. 2010 Feb 26;285(9):5983-92. | ||||
REF 11 | Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature. 2002 Feb 14;415(6873):813-7. |
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