Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T82702 | Target Info | |||
| Target Name | Pregnane X receptor (NR1I2) | ||||
| Synonyms | Steroid and xenobiotic receptor; SXR; PXR; Orphan nuclear receptor PXR; Orphan nuclear receptor PAR1; Nuclear receptor subfamily 1 group I member 2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | NR1I2 | ||||
| Biochemical Class | Nuclear hormone receptor | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acyltransferases | [+] 1 Acyltransferases | + | |||
| Interacting Protein Name | Nuclear receptor coactivator 1 (NCOA1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74 | ||||
| Evidence Score (E-score) | 7 Experimental Evidences | + | |||
| 1 | Co-crystal Structure | [1] | |||
| 2 | Reconstituted Complex | [2] | |||
| 3 | Yeast two hybrid | [3] | |||
| 4 | Yeast two hybrid | [4] | |||
| 5 | Yeast two hybrid | [2] | |||
| 6 | Yeast two hybrid | [5] | |||
| 7 | Yeast two hybrid | [6] | |||
| Nuclear hormone receptors | [+] 2 Nuclear hormone receptors | + | |||
| Interacting Target Name | Hepatocyte nuclear factor 4-alpha (HNF4A) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Transcription factor HNF-4; Transcription factor 14; TCF-14; TCF14; Nuclear receptor subfamily 2 group A member 1; NR2A1; HNF-4-alpha; HNF4 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [7] | |||
| 2 | Reconstituted Complex | [2] | |||
| 3 | Yeast two hybrid | [7] | |||
| Interacting Target Name | Retinoic acid receptor RXR-beta (RXRB) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Retinoid X receptor beta; Nuclear receptor subfamily 2 group B member 2; NR2B2 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [8] | |||
| 2 | Yeast two hybrid | [4] | |||
| Transcription regulators | [+] 2 Transcription regulators | + | |||
| Interacting Protein Name | PPAR-gamma coactivator 1-alpha (PPARGC1A) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | LEM6; PGC.1(alpha); PGC.1v; PGC1; PGC1A; PPARGC1 | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [9] | |||
| 2 | Reconstituted Complex | [9] | |||
| 3 | Reconstituted Complex | [2] | |||
| 4 | Yeast two hybrid | [4] | |||
| Interacting Protein Name | Nuclear receptor corepressor 2 (NCOR2) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CTG26; N.CoR2; SMAP270; SMRT; SMRTE; SMRTE.tau; TNRC14; TRAC; TRAC.1; TRAC1 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Reconstituted Complex | [10] | |||
| 2 | Yeast two hybrid | [10] | |||
| 3 | Yeast two hybrid | [5] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. J Mol Biol. 2003 Aug 22;331(4):815-28. | ||||
| REF 2 | Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression. Drug Metab Dispos. 2006 May;34(5):756-64. | ||||
| REF 3 | RBCK1, an E3 ubiquitin ligase, interacts with and ubiquinates the human pregnane X receptor. Drug Metab Dispos. 2013 Feb;41(2):398-405. | ||||
| REF 4 | Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13. | ||||
| REF 5 | Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics. J Biol Chem. 2002 Sep 6;277(36):32453-8. | ||||
| REF 6 | The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor. Mol Endocrinol. 2008 Apr;22(4):838-57. | ||||
| REF 7 | Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G74-84. | ||||
| REF 8 | Tumor suppressor protein p53 negatively regulates human pregnane X receptor activity. Mol Pharmacol. 2013 Jun;83(6):1229-36. | ||||
| REF 9 | Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepat... J Biol Chem. 2004 Oct 22;279(43):45139-47. | ||||
| REF 10 | Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). Mol Pharmacol. 2006 Jan;69(1):99-108. | ||||
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