Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T79591 Target Info
Target Name Thyroid hormone receptor alpha (THRA)
Synonyms V-erbA-related protein 7; THRA2; THRA1; Nuclear receptor subfamily 1 group A member 1; NR1A1; ERBA1; EAR7; EAR-7; C-erbA-alpha; C-erbA-1
Target Type Successful Target
Gene Name THRA
Biochemical Class Nuclear hormone receptor
UniProt ID
THA_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [3]
Mediator complexes [+] 2 Mediator complexes +
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 1 (MED1) Interacting Protein Interacting Protein Info
UniProt ID
MED1_HUMAN 
Synonyms CRSP1; CRSP200; DRIP205; DRIP230; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Far Western [5]
3 Reconstituted Complex [5]
4 Reconstituted Complex [6]
5 Reconstituted Complex [7]
6 Reconstituted Complex [8]
7 Reconstituted Complex [9]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 21 (MED21) Interacting Protein Interacting Protein Info
UniProt ID
MED21_HUMAN 
Synonyms SRB7; SURB7; hSrb7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Reconstituted Complex [11]
3 Yeast two hybrid [11]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Retinoic acid receptor RXR-alpha (RXRA) Successful Target Interacting Protein Info
UniProt ID
RXRA_HUMAN 
Synonyms RXRalpha; Retinoid X receptor alpha; Nuclear receptor subfamily 2 group B member 1; NR2B1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-localization [12]
3 Co-purification [13]
4 Reconstituted Complex [12]
5 Yeast two hybrid [14]
Transcription regulators [+] 2 Transcription regulators +
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [15]
4 Reconstituted Complex [16]
5 Reconstituted Complex [3]
6 Yeast two hybrid [14]
Interacting Protein Name Nuclear receptor corepressor 2 (NCOR2) Interacting Protein Interacting Protein Info
UniProt ID
NCOR2_HUMAN 
Synonyms CTG26; N.CoR2; SMAP270; SMRT; SMRTE; SMRTE.tau; TNRC14; TRAC; TRAC.1; TRAC1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Far Western [17]
3 Reconstituted Complex [18]
References  Top
REF 1 Temporal formation of distinct thyroid hormone receptor coactivator complexes in HeLa cells. Mol Endocrinol. 2000 Dec;14(12):2001-9.
REF 2 Titration by estrogen receptor activation function-2 of targets that are downstream from coactivators. Mol Endocrinol. 1999 Jun;13(6):897-909.
REF 3 Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity. J Biol Chem. 2007 Mar 30;282(13):9312-22.
REF 4 In vivo repression of an erythroid-specific gene by distinct corepressor complexes. EMBO J. 2002 Mar 15;21(6):1389-97.
REF 5 The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):7939-44.
REF 6 An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature. 2006 Aug 10;442(7103):700-4.
REF 7 Competition between thyroid hormone receptor-associated protein (TRAP) 220 and transcriptional intermediary factor (TIF) 2 for binding to nuclear receptors. Implications for the recruitment of TRAP and p160 coactivator complexes. J Biol Chem. 1999 Mar 5;274(10):6667-77.
REF 8 The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. Mol Cell Biol. 2000 Apr;20(8):2718-26.
REF 9 Gene repressive activity of RIP140 through direct interaction with CDK8. Mol Endocrinol. 2011 Oct;25(10):1689-98.
REF 10 Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol Cell. 1999 Mar;3(3):361-70.
REF 11 hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor. Mol Cell Endocrinol. 2004 Jul 30;222(1-2):41-51.
REF 12 Regulation of AKR1B1 by thyroid hormone and its receptors. Mol Cell Endocrinol. 2009 Aug 13;307(1-2):109-17.
REF 13 RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors. EMBO J. 1992 Apr;11(4):1409-18.
REF 14 Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13.
REF 15 A novel natural mutation in the thyroid hormone receptor defines a dual functional domain that exchanges nuclear receptor corepressors and coactiva... Mol Endocrinol. 1998 Dec;12(12):1888-902.
REF 16 Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature. 1995 Oct 5;377(6548):397-404.
REF 17 Characterization of receptor interaction and transcriptional repression by the corepressor SMRT. Mol Endocrinol. 1997 Dec;11(13):2025-37.
REF 18 Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). Mol Pharmacol. 2006 Jan;69(1):99-108.

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