Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T78181 Target Info
Target Name MTOR complex 2 (RICTOR)
Synonyms hAVO3; Rapamycin-insensitive companion of mTOR; KIAA1999; AVO3 homolog
Target Type Literature-reported Target
Gene Name RICTOR
UniProt ID
RICTR_HUMAN 
Target Interacting Proteins  Top
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name Target of rapamycin complex subunit LST8 (MLST8) Interacting Protein Interacting Protein Info
UniProt ID
LST8_HUMAN 
Synonyms GBL; GbetaL; LST8; POP3; WAT1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Yeast two hybrid [5]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name NAD-dependent deacetylase sirtuin-1 (SIRT1) Clinical trial Target Interacting Protein Info
UniProt ID
SIR1_HUMAN 
Synonyms SIR2-like protein 1; SIR2L1; Regulatory protein SIR2 homolog 1; NAD-dependent protein deacetylase sirtuin-1; hSIRT1; hSIR2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Biochemical Activity [4]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Protein Name Heat shock 70 kDa protein 4 (HSPA4) Interacting Protein Interacting Protein Info
UniProt ID
HSP74_HUMAN 
Synonyms APG.2; HEL.S.5a; HS24/P52; HSPH2; RY; hsp70; hsp70RY
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [5]
3 Yeast two hybrid [5]
Kinases [+] 4 Kinases +
Interacting Target Name Serine/threonine-protein kinase mTOR (mTOR) Successful Target Interacting Protein Info
UniProt ID
MTOR_HUMAN 
Synonyms TOR kinase; Target of rapamycin; RAPT1; Rapamycin target protein 1; Rapamycin target protein; Rapamycin and FKBP12 target 1; RAFT1; Mechanistic target of rapamycin; Mammalian target of rapamycin; FRAP2; FRAP1; FRAP; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein; FK506-binding protein 12-rapamycin complex-associated protein 1
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [2]
4 Affinity Capture-Western [7]
5 Affinity Capture-Western [8]
6 Affinity Capture-Western [9]
7 Affinity Capture-Western [10]
8 Affinity Capture-Western [11]
9 Affinity Capture-Western [12]
10 Affinity Capture-Western [13]
11 Affinity Capture-Western [14]
12 Affinity Capture-Western [15]
13 Affinity Capture-Western [5]
14 Affinity Capture-Western [16]
15 Affinity Capture-Western [4]
16 Affinity Capture-Western [2]
17 Affinity Capture-Western [17]
18 Affinity Capture-Western [18]
19 Affinity Capture-Western [19]
20 Affinity Capture-Western [20]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Biochemical Activity [22]
3 Biochemical Activity [23]
4 Biochemical Activity [11]
5 Biochemical Activity [15]
6 Biochemical Activity [24]
7 Biochemical Activity [25]
8 Co-localization [26]
9 Reconstituted Complex [27]
Interacting Target Name Glycogen synthase kinase-3 beta (GSK-3B) Clinical trial Target Interacting Protein Info
UniProt ID
GSK3B_HUMAN 
Synonyms Serine/threonine-protein kinase GSK3B; GSK-3 beta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Biochemical Activity [27]
Interacting Target Name Ribosomal protein S6 kinase beta-1 (S6K1) Clinical trial Target Interacting Protein Info
UniProt ID
KS6B1_HUMAN 
Synonyms STK14A; Serine/threonine-protein kinase 14A; S6K-beta-1; S6K; Ribosomal protein S6 kinase I; P70S6K1; p70-S6K 1; P70-S6K; p70 S6K-alpha; p70 S6KA; p70 S6 kinase alpha; p70 ribosomal S6 kinase alpha; 70 kDa ribosomal protein S6 kinase 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [26]
2 Reconstituted Complex [29]
Other proteins [+] 2 Other proteins +
Interacting Target Name Target of rapamycin complex 2 MAPKAP1 (MTORC2) Clinical trial Target Interacting Protein Info
UniProt ID
SIN1_HUMAN 
Synonyms TORC2 subunit MAPKAP1; Target of rapamycin complex 2 subunit MAPKAP1; Stress-activated map kinase-interacting protein 1; SIN1; SAPK-interacting protein 1; mSIN1; Mitogen-activated protein kinase 2-associated protein 1; MIP1
Evidence Score (E-score) 15 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-MS [1]
3 Affinity Capture-MS [2]
4 Affinity Capture-Western [30]
5 Affinity Capture-Western [7]
6 Affinity Capture-Western [11]
7 Affinity Capture-Western [12]
8 Affinity Capture-Western [13]
9 Affinity Capture-Western [14]
10 Affinity Capture-Western [15]
11 Affinity Capture-Western [4]
12 Affinity Capture-Western [2]
13 Affinity Capture-Western [19]
14 Reconstituted Complex [27]
15 Yeast two hybrid [5]
Interacting Protein Name Proline-rich protein 5-like (PRR5L) Interacting Protein Interacting Protein Info
UniProt ID
PRR5L_HUMAN 
Synonyms PROTOR2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [31]
4 Affinity Capture-Western [2]
5 Yeast two hybrid [5]
References  Top
REF 1 Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J. 2007 Aug 1;405(3):513-22.
REF 2 PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS One. 2007 Nov 21;2(11):e1217.
REF 3 P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. J Biol Chem. 2007 Aug 10;282(32):23708-15.
REF 4 Multiple site acetylation of Rictor stimulates mammalian target of rapamycin complex 2 (mTORC2)-dependent phosphorylation of Akt protein. J Biol Chem. 2012 Jan 2;287(1):581-8.
REF 5 Hsp70 associates with Rictor and is required for mTORC2 formation and activity. Biochem Biophys Res Commun. 2008 Aug 8;372(4):578-83.
REF 6 Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition. J Biol Chem. 2016 Jan 1;291(1):198-214.
REF 7 SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell. 2006 Oct 6;127(1):125-37.
REF 8 Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol. 2004 Nov;6(11):1122-8.
REF 9 Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol. 2004 Jul 27;14(14):1296-302.
REF 10 Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res. 2008 Mar 15;68(6):1618-24.
REF 11 A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK/PINK1: activation of AKT via mTORC2. J Biol Chem. 2011 Mar 4;286(9):7182-9.
REF 12 Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 2006 Oct 15;20(20):2820-32.
REF 13 mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 2010 Dec 1;29(23):3939-51.
REF 14 The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway. EMBO J. 2009 Dec 16;28(24):3879-92.
REF 15 Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 2008 Jul 23;27(14):1919-31.
REF 16 IKK interacts with rictor and regulates mTORC2. Cell Signal. 2013 Nov;25(11):2239-45.
REF 17 PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell. 2007 Mar 23;25(6):903-15.
REF 18 DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell. 2009 May 29;137(5):873-86.
REF 19 mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol Cell. 2008 Jun 20;30(6):701-11.
REF 20 mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol. 2006 Sep 19;16(18):1865-70.
REF 21 Charting the landscape of tandem BRCT domain-mediated protein interactions. Sci Signal. 2012 Sep 18;5(242):rs6.
REF 22 Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science. 2005 Feb 18;307(5712):1098-101.
REF 23 Synemin promotes AKT-dependent glioblastoma cell proliferation by antagonizing PP2A. Mol Biol Cell. 2012 Apr;23(7):1243-53.
REF 24 Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell. 2006 Apr 21;22(2):159-68.
REF 25 Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem J. 2009 Jun 12;421(1):29-42.
REF 26 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 27 ER stress inhibits mTORC2 and Akt signaling through GSK-3-mediated phosphorylation of rictor. Sci Signal. 2011 Feb 22;4(161):ra10.
REF 28 Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation. J Biol Chem. 2015 May 29;290(22):14120-9.
REF 29 Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J Biol Chem. 2005 May 20;280(20):19445-8.
REF 30 Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell. 2010 Sep 10;39(5):797-808.
REF 31 Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. Cell Signal. 2012 Jan;24(1):309-15.

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