Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T76198 Target Info
Target Name Thromboxane A2 receptor (TBXA2R)
Synonyms TXA2-R; TXA2 receptor; Prostanoid TP receptor
Target Type Successful Target
Gene Name TBXA2R
Biochemical Class GPCR rhodopsin
UniProt ID
TA2R_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Ras-related protein Rab-11A (RAB11A) Interacting Protein Interacting Protein Info
UniProt ID
RB11A_HUMAN 
Synonyms YL8
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Co-localization [3]
4 Protein-peptide [2]
5 Reconstituted Complex [2]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name G protein subunit beta 1 (GNB1) Interacting Protein Interacting Protein Info
UniProt ID
GBB1_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Fluorescence Resonance Energy Transfer [4]
2 Reconstituted Complex [5]
G-protein-coupled receptors [+] 1 G-protein-coupled receptors +
Interacting Target Name Prostacyclin receptor (PTGIR) Successful Target Interacting Protein Info
UniProt ID
PI2R_HUMAN 
Synonyms Prostanoid IP receptor; Prostaglandin I2 receptor; PRIPR; PGI2 receptor; PGI receptor; IP prostanoid receptor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Fluorescence Resonance Energy Transfer [7]
Guanine nucleotide-binding [+] 2 Guanine nucleotide-binding +
Interacting Target Name Guanine nucleotide-binding alpha-q (GNAQ) Literature-reported Target Interacting Protein Info
UniProt ID
GNAQ_HUMAN 
Synonyms GNAQ; G alphaq; G alpha(q)
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [9]
4 Affinity Capture-Western [10]
5 Co-crystal Structure [11]
6 Fluorescence Resonance Energy Transfer [4]
7 Reconstituted Complex [11]
8 Reconstituted Complex [5]
Interacting Protein Name Guanine nucleotide-binding protein subunit alpha-13 (GNA13) Interacting Protein Interacting Protein Info
UniProt ID
GNA13_HUMAN 
Synonyms G13
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Fluorescence Resonance Energy Transfer [4]
3 Reconstituted Complex [5]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Proteasome subunit alpha type-7 (PSMA7) Interacting Protein Interacting Protein Info
UniProt ID
PSA7_HUMAN 
Synonyms C6; HSPC; RC6.1; XAPC7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Yeast two hybrid [13]
3 Yeast two hybrid [14]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Proteasome activator complex subunit 3 (PSME3) Interacting Protein Interacting Protein Info
UniProt ID
PSME3_HUMAN 
Synonyms HEL.S.283; Ki; PA28.gamma; PA28G; PA28gamma; REG.GAMMA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Yeast two hybrid [13]
3 Yeast two hybrid [14]
References  Top
REF 1 Interaction of the human prostacyclin receptor with Rab11: characterization of a novel Rab11 binding domain within alpha-helix 8 that is regulated by palmitoylation. J Biol Chem. 2010 Jun 11;285(24):18709-26.
REF 2 The intracellular trafficking of the G protein-coupled receptor TPbeta depends on a direct interaction with Rab11. J Biol Chem. 2005 Oct 28;280(43):36195-205.
REF 3 Role of the Rab11-associated intracellular pool of receptors formed by constitutive endocytosis of the beta isoform of the thromboxane A2 receptor (TP beta). Biochemistry. 2004 May 18;43(19):5600-7.
REF 4 Real-time monitoring of receptor and G-protein interactions in living cells. Nat Methods. 2005 Mar;2(3):177-84.
REF 5 Protein kinase A-mediated phosphorylation of the Galpha13 switch I region alters the Galphabetagamma13-G protein-coupled receptor complex and inhibits Rho activation. J Biol Chem. 2003 Jan 3;278(1):124-30.
REF 6 Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation. J Biol Chem. 2004 Dec 17;279(51):53036-47.
REF 7 Biased suppression of TP homodimerization and signaling through disruption of a TM GxxxGxxxL helical interaction motif. J Lipid Res. 2013 Jun;54(6):1678-90.
REF 8 WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Gq and phospholipase C in a signalling complex. J Cell Sci. 2011 Oct 1;124(Pt 19):3292-304.
REF 9 The role of N-linked glycosylation in determining the surface expression, G protein interaction and effector coupling of the alpha (alpha) isoform of the human thromboxane A(2) receptor. Biochim Biophys Acta. 2003 May 2;1621(2):192-203.
REF 10 Palmitoylation of Gq determines its association with the thromboxane receptor in hypoxic pulmonary hypertension. Am J Respir Cell Mol Biol. 2014 Jan;50(1):135-43.
REF 11 Structural and functional analysis of the C-terminus of Galphaq in complex with the human thromboxane A2 receptor provides evidence of constitutive activity. Biochemistry. 2010 Aug 3;49(30):6365-74.
REF 12 Cyclic AMP-dependent phosphorylation of thromboxane A(2) receptor-associated Galpha(13). J Biol Chem. 1999 Sep 24;274(39):28003-10.
REF 13 Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes. Prostaglandins Other Lipid Mediat. 2007 Jun;83(4):237-49.
REF 14 [Regulation of G protein-coupled receptor function by its binding proteins]. Yakugaku Zasshi. 2007 Jan;127(1):3-14.

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