Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T76059 Target Info
Target Name FK506-binding protein 1A (FKBP1A)
Synonyms Rotamase; Peptidyl-prolyl cis-trans isomerase FKBP1A; PPIase FKBP1A; Immunophillin FKBP; Immunophilin FKBP12; FKBP12; FKBP1; FKBP-1A; FKBP-12; FK-binding protein 12; Calstabin-1; 12 kDa FKBP; 12 kDa FK506-binding protein
Target Type Successful Target
Gene Name FKBP1A
Biochemical Class Cis-trans-isomerase
UniProt ID
FKB1A_HUMAN 
Target Interacting Proteins  Top
Alpha-type channels [+] 2 Alpha-type channels +
Interacting Target Name Ryanodine receptor 1 (RYR1) Discontinued Target Interacting Protein Info
UniProt ID
RYR1_HUMAN 
Synonyms Type 1 ryanodine receptor; Skeletal muscle-type ryanodine receptor; Skeletal muscle ryanodine receptor; Skeletal muscle calcium release channel; RYR-1; RyR1; RyR; RYDR; Cardiac muscle-type ryanodine receptor; Cardiac muscleryanodine receptor-calcium release channel; Brain-type ryanodine receptor; Brain ryanodine receptor-calcium release channel
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Interacting Target Name IP3 receptor isoform 1 (ITPR1) Literature-reported Target Interacting Protein Info
UniProt ID
ITPR1_HUMAN 
Synonyms Type 1 InsP3 receptor; Type 1 inositol 1,4,5-trisphosphate receptor; IP3R 1; InsP3R1; Inositol 1,4,5-trisphosphate receptor type 1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Yeast two hybrid [4]
Kinases [+] 3 Kinases +
Interacting Target Name Serine/threonine-protein kinase mTOR (mTOR) Successful Target Interacting Protein Info
UniProt ID
MTOR_HUMAN 
Synonyms TOR kinase; Target of rapamycin; RAPT1; Rapamycin target protein 1; Rapamycin target protein; Rapamycin and FKBP12 target 1; RAFT1; Mechanistic target of rapamycin; Mammalian target of rapamycin; FRAP2; FRAP1; FRAP; FKBP-rapamycin associated protein; FKBP12-rapamycin complex-associated protein; FK506-binding protein 12-rapamycin complex-associated protein 1
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [6]
3 Co-crystal Structure [7]
4 Co-crystal Structure [8]
5 Co-fractionation [9]
6 Protein-Fragment Complementation Assay [10]
7 Reconstituted Complex [11]
8 Yeast two hybrid [12]
Interacting Target Name TGF-beta receptor type I (TGFBR1) Clinical trial Target Interacting Protein Info
UniProt ID
TGFR1_HUMAN 
Synonyms Type I TGFbeta receptor kinase; Transforming growth factor-beta receptor type I; TGFR-1; TGF-beta type I receptor; TGF-beta receptor type-1; TbetaR-I; TbetaRI; SKR4; Serine/threonine-protein kinase receptor R4; ALK-5; ALK5; Activin receptor-like kinase 5; Activin A receptor type II-like protein kinase of 53kD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [13]
2 Yeast two hybrid [13]
3 Yeast two hybrid [14]
Interacting Target Name Activin receptor type IB (ACVR1B) Patented-recorded Target Interacting Protein Info
UniProt ID
ACV1B_HUMAN 
Synonyms SKR2; Serine/threonine-protein kinase receptor R2; ALK-4; ALK4; ACVRLK4; ACTR-IB; Activin receptor-like kinase 4; Activin receptor type-1B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Protein-Fragment Complementation Assay [16]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Glomulin (GLMN) Interacting Protein Interacting Protein Info
UniProt ID
GLMN_HUMAN 
Synonyms FAP; FAP48; FAP68; FKBPAP; GLML; GVM; VMGLOM
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [17]
2 Reconstituted Complex [18]
3 Yeast two hybrid [18]
References  Top
REF 1 FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes. J Biol Chem. 2003 Jun 20;278(25):22600-8.
REF 2 FKBP12 binding modulates ryanodine receptor channel gating. J Biol Chem. 2001 May 18;276(20):16931-5.
REF 3 In smooth muscle, FK506-binding protein modulates IP3 receptor-evoked Ca2+ release by mTOR and calcineurin. J Cell Sci. 2005 Dec 1;118(Pt 23):5443-51.
REF 4 FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain. J Biol Chem. 1997 Oct 31;272(44):27582-8.
REF 5 Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol. 2004 Nov;6(11):1122-8.
REF 6 Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol. 2004 Jul 27;14(14):1296-302.
REF 7 Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science. 1996 Jul 12;273(5272):239-42.
REF 8 Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution. Acta Crystallogr D Biol Crystallogr. 1999 Apr;55(Pt 4):736-44.
REF 9 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 10 Dual-color click beetle luciferase heteroprotein fragment complementation assays. Chem Biol. 2010 Sep 24;17(9):1018-29.
REF 11 Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem. 1995 Jan 13;270(2):815-22.
REF 12 Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12288-93.
REF 13 Specific interaction of type I receptors of the TGF-beta family with the immunophilin FKBP-12. Science. 1994 Jul 29;265(5172):674-6.
REF 14 Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol Cell Biol. 1995 Jul;15(7):3479-86.
REF 15 FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. J Mol Endocrinol. 2006 Jun;36(3):569-79.
REF 16 Reverse MAPPIT: screening for protein-protein interaction modifiers in mammalian cells. Nat Methods. 2005 Jun;2(6):427-33.
REF 17 FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin. J Biol Chem. 1996 Dec 20;271(51):32923-9.
REF 18 Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52. Regul Pept. 2001 Mar 2;97(2-3):147-52.

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