Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T75644 Target Info
Target Name Suppressor of G2 allele of SKP1 homolog (Sgt1)
Synonyms Protein SGT1 homolog; Protein 40-6-3
Target Type Literature-reported Target
Gene Name SUGT1
UniProt ID
SGT1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase NRDP1 (RNF41) Interacting Protein Interacting Protein Info
UniProt ID
RNF41_HUMAN 
Synonyms FLRF; NRDP1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [1]
3 Affinity Capture-Western [2]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [5]
5 Co-crystal Structure [6]
6 Co-localization [7]
7 Reconstituted Complex [6]
8 Reconstituted Complex [8]
9 Reconstituted Complex [5]
Other proteins [+] 5 Other proteins +
Interacting Protein Name Kinetochore-associated protein DSN1 homolog (DSN1) Interacting Protein Interacting Protein Info
UniProt ID
DSN1_HUMAN 
Synonyms C20orf172; KNL3; MIS13; dJ469A13.2; hKNL.3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [9]
3 Reconstituted Complex [8]
Interacting Protein Name S-phase kinase-associated protein 1 (SKP1) Interacting Protein Interacting Protein Info
UniProt ID
SKP1_HUMAN 
Synonyms EMC19; OCP.II; OCP2; SKP1A; TCEB1L; p19A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [10]
3 Reconstituted Complex [11]
Interacting Protein Name Protein MIS12 homolog (MIS12) Interacting Protein Interacting Protein Info
UniProt ID
MIS12_HUMAN 
Synonyms 2510025F08Rik; KNTC2AP; MTW1; hMis12
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [9]
Interacting Protein Name Kinetochore-associated protein NSL1 homolog (NSL1) Interacting Protein Interacting Protein Info
UniProt ID
NSL1_HUMAN 
Synonyms C1orf48; MIS14
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [9]
Interacting Protein Name Polyamine-modulated factor 1 (PMF1) Interacting Protein Interacting Protein Info
UniProt ID
PMF1_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [9]
References  Top
REF 1 A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell. 2014 Jul 17;158(2):434-448.
REF 2 Interplay between the phosphatase PHLPP1 and E3 ligase RNF41 stimulates proper kinetochore assembly via the outer-kinetochore protein SGT1. J Biol Chem. 2017 Aug 25;292(34):13947-13958.
REF 3 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation. Oncogene. 2006 Jul 13;25(30):4133-46.
REF 4 A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. Nat Immunol. 2007 May;8(5):497-503.
REF 5 Hsp70 is a new target of Sgt1--an interaction modulated by S100A6. Biochem Biophys Res Commun. 2007 Jun 15;357(4):1148-53.
REF 6 Human Sgt1 binds HSP90 through the CHORD-Sgt1 domain and not the tetratricopeptide repeat domain. J Biol Chem. 2004 Apr 16;279(16):16511-7.
REF 7 Calcyclin Binding Protein/Siah-1 Interacting Protein Is a Hsp90 Binding Chaperone. PLoS One. 2016 Jun 1;11(6):e0156507.
REF 8 Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment. Mol Cell Biol. 2012 Oct;32(19):4053-67.
REF 9 Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites. J Cell Biol. 2010 Apr 19;189(2):261-74.
REF 10 Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. J Biol Chem. 2003 Jul 18;278(29):26923-8.
REF 11 Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes. EMBO J. 2008 Oct 22;27(20):2789-98.

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