Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T71055 Target Info
Target Name Linear ubiquitin chain assembly complex (RBCK1)
Synonyms XAP4; XAP3; Ubiquitin-conjugating enzyme 7-interacting protein 3; UBCE7IP3; RanBP-type and C3HC4-type zinc finger-containing protein 1; RNF54; RING-type E3 ubiquitin transferase HOIL-1; RING finger protein 54; Hepatitis B virus X-associated protein 4; Heme-oxidized IRP2 ubiquitin ligase 1; HOIL-1; HBV-associated factor 4; C20orf18
Target Type Literature-reported Target
Gene Name RBCK1
Biochemical Class Acyltransferase
UniProt ID
HOIL1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase RNF31 (RNF31) Interacting Protein Interacting Protein Info
UniProt ID
RNF31_HUMAN 
Synonyms HOIP; ZIBRA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Co-fractionation [4]
Interacting Target Name Zinc finger protein A20 (TNFAIP3) Literature-reported Target Interacting Protein Info
UniProt ID
TNAP3_HUMAN 
Synonyms Tumor necrosis factor, alpha-induced protein3; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; Putative DNA-binding protein A20; Putative DNA binding protein A20; OTUD7C; OTU domain-containing protein 7C; A20
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Yeast two hybrid [6]
Isomerases [+] 1 Isomerases +
Interacting Protein Name Iron-responsive element-binding protein 2 (IREB2) Interacting Protein Interacting Protein Info
UniProt ID
IREB2_HUMAN 
Synonyms ACO3; IRP2; IRP2AD
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [8]
3 Biochemical Activity [7]
Kinases [+] 1 Kinases +
Interacting Target Name Protein kinase C beta (PRKCB) Clinical trial Target Interacting Protein Info
UniProt ID
KPCB_HUMAN 
Synonyms Protein kinase C beta type; Protein Kinase C beta; PRKCB1; PKC-beta; PKC-B; PKCB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Biochemical Activity [10]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Affinity Capture-Western [12]
3 Reconstituted Complex [11]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Affinity Capture-Western [13]
3 Biochemical Activity [4]
4 Biochemical Activity [14]
5 Co-crystal Structure [15]
6 Reconstituted Complex [13]
7 Reconstituted Complex [14]
8 Reconstituted Complex [15]
Other proteins [+] 2 Other proteins +
Interacting Target Name Tumor necrosis factor (TNF) Successful Target Interacting Protein Info
UniProt ID
TNFA_HUMAN 
Synonyms Tumour necrosis factor alpha; Tumour necrosis factor; Tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor; TNFSF2; TNF-alpha; TNFalpha; TNF-a; TNFA; TNF alpha; Cachectin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-Western [5]
Interacting Protein Name NF-kappa-B essential modulator (IKBKG) Interacting Protein Interacting Protein Info
UniProt ID
NEMO_HUMAN 
Synonyms AMCBX1; FIP.3; FIP3; Fip3p; IKK.gamma; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Biochemical Activity [18]
References  Top
REF 1 The hepatitis C virus protein NS3 suppresses TNF--stimulated activation of NF-B by targeting LUBAC. Sci Signal. 2015 Nov 17;8(403):ra118.
REF 2 SHARPIN is a component of the NF-B-activating linear ubiquitin chain assembly complex. Nature. 2011 Mar 31;471(7340):633-6.
REF 3 The paracaspase MALT1 cleaves HOIL1 reducing linear ubiquitination by LUBAC to dampen lymphocyte NF-B signalling. Nat Commun. 2015 Nov 3;6:8777.
REF 4 A ubiquitin ligase complex assembles linear polyubiquitin chains. EMBO J. 2006 Oct 18;25(20):4877-87.
REF 5 A20 inhibits LUBAC-mediated NF-B activation by binding linear polyubiquitin chains via its zinc finger 7. EMBO J. 2012 Oct 3;31(19):3845-55.
REF 6 Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. J Biol Chem. 2012 Dec 14;287(51):43007-18.
REF 7 Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2. Nat Cell Biol. 2003 Apr;5(4):336-40.
REF 8 HOIL-1 is not required for iron-mediated IRP2 degradation in HEK293 cells. Biochim Biophys Acta. 2008 Feb;1783(2):246-52.
REF 9 RBCK1, a protein kinase CbetaI (PKCbetaI)-interacting protein, regulates PKCbeta-dependent function. J Biol Chem. 2007 Jan 19;282(3):1650-7.
REF 10 Identification of ubiquitin ligase activity of RBCK1 and its inhibition by splice variant RBCK2 and protein kinase Cbeta. J Biol Chem. 2008 Apr 25;283(17):11575-85.
REF 11 Estrogen receptor-, RBCK1, and protein kinase C 1 cooperate to regulate estrogen receptor- gene expression. J Mol Endocrinol. 2012 Oct 30;49(3):277-87.
REF 12 Identification of RBCK1 as a novel regulator of FKBPL: implications for tumor growth and response to tamoxifen. Oncogene. 2014 Jun 26;33(26):3441-50.
REF 13 Accumulation of polyubiquitinated proteins by overexpression of RBCC protein interacting with protein kinase C2, a splice variant of ubiquitin ligase RBCC protein interacting with protein kinase C1. FEBS J. 2009 Nov;276(21):6375-85.
REF 14 Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains. Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15247-52.
REF 15 Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20520-5.
REF 16 Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction. Mol Cell. 2009 Dec 11;36(5):831-44.
REF 17 The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease. Nat Immunol. 2017 Jan;18(1):26-35.
REF 18 Direct activation of protein kinases by unanchored polyubiquitin chains. Nature. 2009 Sep 3;461(7260):114-9.

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