Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T68470 Target Info
Target Name Deubiquitinating enzyme 1 (USP1)
Synonyms hUBP; Ubiquitin-specific-processing protease 1; Ubiquitin thioesterase 1; Ubiquitin carboxyl-terminal hydrolase 1
Target Type Literature-reported Target
Gene Name USP1
Biochemical Class Peptidase
UniProt ID
UBP1_HUMAN 
Target Interacting Proteins  Top
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name WD repeat-containing protein 48 (WDR48) Interacting Protein Interacting Protein Info
UniProt ID
WDR48_HUMAN 
Synonyms P80; SPG60; UAF1
Evidence Score (E-score) 15 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Affinity Capture-MS [5]
6 Affinity Capture-Western [4]
7 Affinity Capture-Western [6]
8 Affinity Capture-Western [7]
9 Affinity Capture-Western [8]
10 Affinity Capture-Western [9]
11 Co-localization [8]
12 Co-purification [4]
13 Reconstituted Complex [4]
14 Reconstituted Complex [10]
15 Reconstituted Complex [11]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name PH domain leucine-rich repeat-containing protein phosphatase 1 (PHLPP1) Interacting Protein Interacting Protein Info
UniProt ID
PHLP1_HUMAN 
Synonyms PHLPP; PLEKHE1; SCOP
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [5]
4 Affinity Capture-Western [12]
5 Reconstituted Complex [12]
Membrane-bounded channels [+] 1 Membrane-bounded channels +
Interacting Protein Name Importin subunit alpha-5 (KPNA1) Interacting Protein Interacting Protein Info
UniProt ID
IMA5_HUMAN 
Synonyms IPOA5; NPI.1; RCH2; SRP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [13]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Fanconi anemia group D2 protein (FANCD2) Interacting Protein Interacting Protein Info
UniProt ID
FACD2_HUMAN 
Synonyms FA.D2; FA4; FACD; FAD; FAD2; FANCD
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Biochemical Activity [4]
3 Biochemical Activity [10]
4 Co-fractionation [14]
References  Top
REF 1 Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.
REF 2 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 3 Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1. J Biol Chem. 2010 Apr 2;285(14):10362-9.
REF 4 A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway. Mol Cell. 2007 Dec 14;28(5):786-97.
REF 5 The USP1-UAF1 complex interacts with RAD51AP1 to promote homologous recombination repair. Cell Cycle. 2016 Oct;15(19):2636-2646.
REF 6 Two nuclear localization signals in USP1 mediate nuclear import of the USP1/UAF1 complex. PLoS One. 2012;7(6):e38570.
REF 7 UAF1 is a subunit of multiple deubiquitinating enzyme complexes. J Biol Chem. 2009 Feb 20;284(8):5343-51.
REF 8 Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage. Mol Cancer. 2015 Feb 6;14:33.
REF 9 Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46. Structure. 2015 Nov 3;23(11):2043-54.
REF 10 Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway. Mol Cell. 2017 Jan 19;65(2):247-259.
REF 11 Serine phosphorylation is critical for the activation of ubiquitin-specific protease 1 and its interaction with WD40-repeat protein UAF1. Biochemistry. 2012 Nov 13;51(45):9112-23.
REF 12 USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells. J Cancer Res Clin Oncol. 2012 Jul;138(7):1231-8.
REF 13 Exploring the link between MORF4L1 and risk of breast cancer. Breast Cancer Res. 2011 Apr 5;13(2):R40.
REF 14 The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Mol Cell. 2005 Feb 4;17(3):331-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.