Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T63024 Target Info
Target Name NF-kappa-B-activating kinase (TBK1)
Synonyms TANK-binding kinase 1; T2K; Serine/threonine-protein kinase TBK1; NAK
Target Type Patented-recorded Target
Gene Name TBK1
Biochemical Class Kinase
UniProt ID
TBK1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Target Name Zinc finger protein A20 (TNFAIP3) Literature-reported Target Interacting Protein Info
UniProt ID
TNAP3_HUMAN 
Synonyms Tumor necrosis factor, alpha-induced protein3; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; Putative DNA-binding protein A20; Putative DNA binding protein A20; OTUD7C; OTU domain-containing protein 7C; A20
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Interacting Target Name TNF receptor-associated factor 6 (TRAF6) Literature-reported Target Interacting Protein Info
UniProt ID
TRAF6_HUMAN 
Synonyms RNF85; RING-type E3 ubiquitin transferase TRAF6; RING finger protein 85; Interleukin-1 signal transducer; E3 ubiquitin-protein ligase TRAF6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
Adapter proteins [+] 3 Adapter proteins +
Interacting Protein Name TRAF family member-associated NF-kappa-B activator (TANK) Interacting Protein Interacting Protein Info
UniProt ID
TANK_HUMAN 
Synonyms I.TRAF; ITRAF; TRAF2
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-MS [6]
3 Affinity Capture-MS [7]
4 Affinity Capture-Western [8]
5 Yeast two hybrid [9]
Interacting Protein Name NF-kappa-B-activating kinase-associated protein 1 (AZI2) Interacting Protein Interacting Protein Info
UniProt ID
AZI2_HUMAN 
Synonyms AZ2; NAP1; TILP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-MS [6]
3 Affinity Capture-Western [10]
4 Co-fractionation [10]
Interacting Protein Name TANK-binding kinase 1-binding protein 1 (TBKBP1) Interacting Protein Interacting Protein Info
UniProt ID
TBKB1_HUMAN 
Synonyms ProSAPiP2; SINTBAD
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-MS [6]
3 Affinity Capture-MS [7]
4 Affinity Capture-Western [8]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [11]
2 Affinity Capture-Western [12]
Kinases [+] 1 Kinases +
Interacting Protein Name Inhibitor of nuclear factor kappa-B kinase (IKK) Interacting Protein Interacting Protein Info
UniProt ID
IKKE_HUMAN 
Synonyms IKK.E; IKK.i; IKKE; IKKI
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [13]
3 Reconstituted Complex [14]
4 Reconstituted Complex [13]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD) Interacting Protein Interacting Protein Info
UniProt ID
CYLD_HUMAN 
Synonyms BRSS; CDMT; CYLD1; CYLDI; EAC; MFT; MFT1; SBS; TEM; USPL2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Affinity Capture-Western [16]
3 Biochemical Activity [17]
4 Co-localization [16]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name Interferon regulatory factor 3 (IRF3) Literature-reported Target Interacting Protein Info
UniProt ID
IRF3_HUMAN 
Synonyms IRF-3
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [15]
3 Affinity Capture-Western [18]
4 Affinity Capture-Western [12]
5 Affinity Capture-Western [19]
6 Biochemical Activity [20]
7 Biochemical Activity [21]
8 Biochemical Activity [22]
9 Biochemical Activity [23]
10 Biochemical Activity [24]
11 Reconstituted Complex [14]
12 Yeast two hybrid [14]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Biochemical Activity [25]
3 Biochemical Activity [10]
Other proteins [+] 5 Other proteins +
Interacting Protein Name Optineurin (OPTN) Interacting Protein Interacting Protein Info
UniProt ID
OPTN_HUMAN 
Synonyms ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA.INTP
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [26]
3 Affinity Capture-Western [27]
4 Affinity Capture-Western [8]
5 Biochemical Activity [28]
6 Biochemical Activity [16]
7 Biochemical Activity [8]
8 Co-localization [16]
9 Reconstituted Complex [6]
Interacting Protein Name Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) Interacting Protein Interacting Protein Info
UniProt ID
CACO2_HUMAN 
Synonyms NDP52
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [29]
3 Reconstituted Complex [6]
Interacting Protein Name Mitochondrial antiviral-signaling protein (MAVS) Interacting Protein Interacting Protein Info
UniProt ID
MAVS_HUMAN 
Synonyms CARDIF; IPS.1; IPS1; VISA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [30]
3 Biochemical Activity [31]
Interacting Target Name Tumor necrosis factor (TNF) Successful Target Interacting Protein Info
UniProt ID
TNFA_HUMAN 
Synonyms Tumour necrosis factor alpha; Tumour necrosis factor; Tumor necrosis factor ligand superfamily member 2; Tumor necrosis factor; TNFSF2; TNF-alpha; TNFalpha; TNF-a; TNFA; TNF alpha; Cachectin
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [32]
2 Affinity Capture-Western [33]
Interacting Target Name TIR domain-containing adapter molecule 1 (TICAM1) Patented-recorded Target Interacting Protein Info
UniProt ID
TCAM1_HUMAN 
Synonyms TRIF; Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta; TIR domain-containing adapter protein inducing IFN-beta; TICAM-1; Putative NF-kappa-B-activating protein 502H; PRVTIRB; Proline-rich, vinculin and TIR domain-containing protein B; MyD88-3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Affinity Capture-Western [20]
References  Top
REF 1 Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.
REF 2 ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling. J Biol Chem. 2011 Oct 21;286(42):36592-602.
REF 3 FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions. MBio. 2017 Jan 3;8(1). pii: e02161-16.
REF 4 MAVS activates TBK1 and IKK through TRAFs in NEMO dependent and independent manner. PLoS Pathog. 2017 Nov 10;13(11):e1006720.
REF 5 Identification of proteins that interact with TANK binding kinase 1 and testing for mutations associated with glaucoma. Curr Eye Res. 2013 Feb;38(2):310-5.
REF 6 Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity. 2011 Sep 23;35(3):426-40.
REF 7 A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol. 2004 Feb;6(2):97-105.
REF 8 Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proc Natl Acad Sci U S A. 2016 Apr 12;113(15):4039-44.
REF 9 MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation. Cell Death Differ. 2014 May;21(5):811-24.
REF 10 Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Mol Cell Biol. 2003 Nov;23(21):7780-93.
REF 11 Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001.
REF 12 Hsp90 regulates activation of interferon regulatory factor 3 and TBK-1 stabilization in Sendai virus-infected cells. Mol Biol Cell. 2006 Mar;17(3):1461-71.
REF 13 SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity. Mol Cell Biol. 2015 Jul;35(14):2400-13.
REF 14 Involvement of the ubiquitin-like domain of TBK1/IKK-i kinases in regulation of IFN-inducible genes. EMBO J. 2007 Jul 25;26(14):3451-62.
REF 15 The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. EMBO Rep. 2008 Sep;9(9):930-6.
REF 16 Optineurin regulates the interferon response in a cell cycle-dependent manner. PLoS Pathog. 2015 Apr 29;11(4):e1004877.
REF 17 Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKK/TBK1 as a Case Study. Front Cell Dev Biol. 2018 Apr 10;6:40.
REF 18 FKBP8 inhibits virus-induced RLR-VISA signaling. J Med Virol. 2019 Mar;91(3):482-492.
REF 19 MIP-T3 is a negative regulator of innate type I IFN response. J Immunol. 2011 Dec 15;187(12):6473-82.
REF 20 Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling. J Leukoc Biol. 2009 Oct;86(4):863-75.
REF 21 IB kinase -dependent phosphorylation and degradation of X-linked inhibitor of apoptosis sensitizes cells to virus-induced apoptosis. J Virol. 2012 Jan;86(2):726-37.
REF 22 Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade. Nat Cell Biol. 2017 Apr;19(4):362-374.
REF 23 Tom70 mediates activation of interferon regulatory factor 3 on mitochondria. Cell Res. 2010 Sep;20(9):994-1011.
REF 24 NEMO binds ubiquitinated TANK-binding kinase 1 (TBK1) to regulate innate immune responses to RNA viruses. PLoS One. 2012;7(9):e43756.
REF 25 Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription. J Biol Chem. 2004 Dec 31;279(53):55633-43.
REF 26 Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection. PLoS Pathog. 2010 Feb 19;6(2):e1000778.
REF 27 Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia. Nat Neurosci. 2015 May;18(5):631-6.
REF 28 The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy. Mol Cell. 2015 Oct 1;60(1):7-20.
REF 29 The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat Immunol. 2009 Nov;10(11):1215-21.
REF 30 VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell. 2005 Sep 16;19(6):727-40.
REF 31 Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science. 2015 Mar 13;347(6227):aaa2630.
REF 32 NAK is recruited to the TNFR1 complex in a TNFalpha-dependent manner and mediates the production of RANTES: identification of endogenous TNFR-inter... J Biol Chem. 2004 Dec 17;279(51):53266-71.
REF 33 SPATA2 links CYLD to the TNF- receptor signaling complex and modulates the receptor signaling outcomes. EMBO J. 2016 Sep 1;35(17):1868-84.

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