Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T62431 Target Info
Target Name Tyrosine-protein kinase SYK (SYK)
Synonyms p72-Syk; Spleen tyrosine kinase
Target Type Successful Target
Gene Name SYK
Biochemical Class Kinase
UniProt ID
KSYK_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Signal transduction protein CBL (CBL) Literature-reported Target Interacting Protein Info
UniProt ID
CBL_HUMAN 
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Co-localization [3]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase SHP-1 (PTPN6) Patented-recorded Target Interacting Protein Info
UniProt ID
PTN6_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 6; SH-PTP1; PTP-1C; PTP1C; Protein-tyrosine phosphatase 1C; Hematopoietic cell protein-tyrosine phosphatase; HCP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Biochemical Activity [5]
Kinases [+] 2 Kinases +
Interacting Protein Name Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) Interacting Protein Interacting Protein Info
UniProt ID
P85A_HUMAN 
Synonyms AGM7; GRB1; IMD36; p85; p85.ALPHA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [7]
3 Yeast two hybrid [7]
Interacting Target Name Tyrosine-protein kinase Fgr (FGR) Literature-reported Target Interacting Protein Info
UniProt ID
FGR_HUMAN 
Synonyms SRC2; Proto-oncogene c-Fgr; p58-Fgr; p58c-Fgr; p55-Fgr; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Yeast two hybrid [7]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Ubiquitin carboxyl-terminal hydrolase 25 (USP25) Interacting Protein Interacting Protein Info
UniProt ID
UBP25_HUMAN 
Synonyms USP21
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Yeast two hybrid [9]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name E3 ubiquitin protein ligase CBLB (CBLB) Literature-reported Target Interacting Protein Info
UniProt ID
CBLB_HUMAN 
Synonyms Signal transduction protein CBL-B; Signal transduction protein CBLB; SH3-binding protein CBL-B; SH3binding protein CBLB; RNF56; RING-type E3 ubiquitin transferase CBL-B; RING finger protein 56; Nbla00127; E3 ubiquitin-protein ligase CBL-B; E3 ubiquitinprotein ligase CBLB; Casitas B-lineage lymphoma proto-oncogene b; Casitas Blineage lymphoma protooncogene b
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Biochemical Activity [11]
Other proteins [+] 2 Other proteins +
Interacting Protein Name Src substrate cortactin (CTTN) Interacting Protein Interacting Protein Info
UniProt ID
SRC8_HUMAN 
Synonyms EMS1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Co-localization [13]
Interacting Protein Name Proto-oncogene vav (VAV1) Interacting Protein Interacting Protein Info
UniProt ID
VAV_HUMAN 
Synonyms VAV
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [14]
2 Yeast two hybrid [15]
References  Top
REF 1 Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human neutrophils. Biochem J. 2003 Mar 1;370(Pt 2):687-94.
REF 2 Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl. FEBS Lett. 2004 Nov 19;577(3):555-62.
REF 3 DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk. Elife. 2016 Sep 10;5. pii: e16370.
REF 4 Beta-chemokine receptor CCR5 signals through SHP1, SHP2, and Syk. J Biol Chem. 2000 Jun 9;275(23):17263-8.
REF 5 Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased Syk tyrosine kinase activity and B cell activation. J Immunol. 1999 Mar 1;162(5):2717-24.
REF 6 Differential kinase requirements in human and mouse Fc-gamma receptor phagocytosis and endocytosis. J Leukoc Biol. 2006 Dec;80(6):1553-62.
REF 7 Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase. J Biol Chem. 2005 Jan 14;280(2):1543-51.
REF 8 Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity. 2001 Oct;15(4):507-19.
REF 9 Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase. Exp Cell Res. 2010 Feb 15;316(4):667-75.
REF 10 Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. Oncogene. 1999 Feb 4;18(5):1147-56.
REF 11 Inhibition of CBLB protects from lethal Candida albicans sepsis. Nat Med. 2016 Aug;22(8):915-23.
REF 12 Physical and functional association of cortactin with Syk in human leukemic cell line K562. J Biol Chem. 1996 Mar 22;271(12):6631-5.
REF 13 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 14 Requirement of tyrosine-phosphorylated Vav for morphological differentiation of all-trans-retinoic acid-treated HL-60 cells. Cell Growth Differ. 2001 Apr;12(4):193-200.
REF 15 Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product. Immunity. 1996 Dec;5(6):591-604.

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