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| Target General Information |
Top |
| Target ID |
T60724 |
Target Info
|
| Target Name |
Sclerostin (SOST) |
| Synonyms |
UNQ2976/PRO7455/PRO7476 |
| Target Type |
Successful Target |
| Gene Name |
SOST |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Putative transporters |
[+] 2 Putative transporters |
+ |
| Interacting Target Name |
LDL receptor related protein-6 (LRP-6) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Low-density lipoprotein receptor-related protein 6 |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| Interacting Protein Name |
Low-density lipoprotein receptor-related protein 5 (LRP5) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
BMND1; EVR1; EVR4; HBM; LR3; LRP.5; LRP7; OPPG; OPS; OPTA1; VBCH2 |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| References |
Top |
| REF 1 |
Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
|
| REF 2 |
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor. J Biol Chem. 2005 Jul 22;280(29):26770-5.
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