Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T59190 Target Info
Target Name Protein kinase C zeta (PRKCZ)
Synonyms Protein kinase C zeta type; PKC2; NPKC-zeta
Target Type Patented-recorded Target
Gene Name PRKCZ
Biochemical Class Kinase
UniProt ID
KPCZ_HUMAN 
Target Interacting Proteins  Top
Actins [+] 1 Actins +
Interacting Protein Name Cofilin-1 (CFL1) Interacting Protein Interacting Protein Info
UniProt ID
COF1_HUMAN 
Synonyms CFL; HEL.S.15
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 SUMO-protein ligase PIAS4 (PIAS4) Interacting Protein Interacting Protein Info
UniProt ID
PIAS4_HUMAN 
Synonyms PIASY; Piasg; ZMIZ6
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [3]
2 Yeast two hybrid [4]
Adapter proteins [+] 3 Adapter proteins +
Interacting Target Name Sequestosome-1 p62 (SQSTM1) Literature-reported Target Interacting Protein Info
UniProt ID
SQSTM_HUMAN 
Synonyms Ubiquitin-binding protein p62; Sequestosome-1; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62kDa; Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; OSIL; ORCA; EBIAP; EBI3-associated protein of 60 kDa
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [5]
3 Co-localization [6]
4 Protein-peptide [7]
5 Reconstituted Complex [8]
Interacting Protein Name Partitioning defective 6 homolog alpha (PARD6A) Interacting Protein Interacting Protein Info
UniProt ID
PAR6A_HUMAN 
Synonyms PAR.6A; PAR6; PAR6C; PAR6alpha; TAX40; TIP.40
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Affinity Capture-Western [6]
3 Yeast two hybrid [10]
Interacting Protein Name Partitioning defective 6 homolog beta (PARD6B) Interacting Protein Interacting Protein Info
UniProt ID
PAR6B_HUMAN 
Synonyms PAR6B
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [11]
3 Yeast two hybrid [12]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name 14-3-3 protein zeta/delta (YWHAZ) Interacting Protein Interacting Protein Info
UniProt ID
1433Z_HUMAN 
Synonyms 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Biochemical Activity [13]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [14]
3 Yeast two hybrid [15]
Kinases [+] 5 Kinases +
Interacting Target Name Phosphoinositide dependent protein kinase-1 (PDPK1) Clinical trial Target Interacting Protein Info
UniProt ID
PDPK1_HUMAN 
Synonyms PDK1; HPDK1; 3-phosphoinositide-dependent protein kinase 1; 3-Phosphoinositide-dependent kinase-1; 3'-phosphoinositide dependent kinase 1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Biochemical Activity [16]
3 Reconstituted Complex [17]
4 Yeast two hybrid [18]
Interacting Target Name RAC-gamma serine/threonine-protein kinase (AKT3) Successful Target Interacting Protein Info
UniProt ID
AKT3_HUMAN 
Synonyms STK-2; RAC-PK-gamma; Protein kinase B gamma; Protein kinase Akt-3; PKBG; PKB gamma
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Biochemical Activity [19]
3 Co-localization [20]
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [21]
2 Yeast two hybrid [22]
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [23]
2 Biochemical Activity [24]
Interacting Protein Name Casein kinase II subunit beta (CSNK2B) Interacting Protein Interacting Protein Info
UniProt ID
CSK2B_HUMAN 
Synonyms CK2B; CK2N; CSK2B; G5A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [25]
Proteins 14-3-3 [+] 1 Proteins 14-3-3 +
Interacting Protein Name 14-3-3 protein beta/alpha (YWHAB) Interacting Protein Interacting Protein Info
UniProt ID
1433B_HUMAN 
Synonyms GW128; HEL.S.1; HS1; KCIP.1; YWHAA
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [13]
2 Yeast two hybrid [26]
Putative transporters [+] 1 Putative transporters +
Interacting Protein Name Hyaluronan-binding protein 1 (C1QBP) Interacting Protein Interacting Protein Info
UniProt ID
C1QBP_HUMAN 
Synonyms GC1QBP; HABP1; SF2p32; gC1Q.R; gC1qR; p32
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name Transcription factor Sp1 (SP1) Clinical trial Target Interacting Protein Info
UniProt ID
SP1_HUMAN 
Synonyms TSFP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [27]
2 Biochemical Activity [28]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [29]
2 Biochemical Activity [29]
Other proteins [+] 2 Other proteins +
Interacting Target Name Nucleophosmin (NPM1) Clinical trial Target Interacting Protein Info
UniProt ID
NPM_HUMAN 
Synonyms Numatrin; Nucleolar protein NO38; Nucleolar phosphoprotein B23; NPM
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Interacting Protein Name Protein KIBRA (WWC1) Interacting Protein Interacting Protein Info
UniProt ID
KIBRA_HUMAN 
Synonyms HBEBP3; HBEBP36; KIBRA; MEMRYQTL; PPP1R168
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Biochemical Activity [30]
References  Top
REF 1 Profiling the interactome of protein kinase C by proteomics and bioinformatics. Proteome Sci. 2018 Feb 26;16:5.
REF 2 Quantitative study of the interactome of PKC involved in the EGF-induced tumor cell chemotaxis. J Proteome Res. 2013 Mar 1;12(3):1478-86.
REF 3 Ubiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4. J Exp Med. 2016 May 30;213(6):1029-46.
REF 4 PKC mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. J Cell Biol. 2011 May 30;193(5):867-84.
REF 5 p62 binding to protein kinase C regulates tumor necrosis factor -induced apoptotic pathway in endothelial cells. Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):2974-80.
REF 6 Protein Scaffolds Control Localized Protein Kinase C Activity. J Biol Chem. 2016 Jun 24;291(26):13809-22.
REF 7 Zeta Inhibitory Peptide Disrupts Electrostatic Interactions That Maintain Atypical Protein Kinase C in Its Active Conformation on the Scaffold p62. J Biol Chem. 2015 Sep 4;290(36):21845-56.
REF 8 Solution structure of atypical protein kinase C PB1 domain and its mode of interaction with ZIP/p62 and MEK5. J Biol Chem. 2004 Jul 23;279(30):31883-90.
REF 9 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 10 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.
REF 11 Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. Genes Cells. 2001 Feb;6(2):107-19.
REF 12 Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol Syst Biol. 2016 Apr 22;12(4):863.
REF 13 14-3-3 isotypes facilitate coupling of protein kinase C-zeta to Raf-1: negative regulation by 14-3-3 phosphorylation. Biochem J. 2000 Jan 15;345 Pt 2:297-306.
REF 14 Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001.
REF 15 A human MAP kinase interactome. Nat Methods. 2010 Oct;7(10):801-5.
REF 16 Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science. 1998 Sep 25;281(5385):2042-5.
REF 17 A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1. J Biol Chem. 2000 Jul 7;275(27):20806-13.
REF 18 Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment. Biochemistry. 2002 Jan 15;41(2):561-9.
REF 19 Characterization of PDK2 activity against protein kinase B gamma. Biochemistry. 2002 Aug 13;41(32):10351-9.
REF 20 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 21 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 22 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 23 Protein kinase Czeta is a negative regulator of protein kinase B activity. J Biol Chem. 1999 Mar 26;274(13):8589-96.
REF 24 Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis. EMBO J. 2008 Aug 20;27(16):2181-93.
REF 25 PKC-zeta-associated CK2 participates in the turnover of free IkappaBalpha. J Mol Biol. 2000 Apr 14;297(5):1245-58.
REF 26 A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.
REF 27 Phosphatidylinositol 3-kinase/protein kinase Czeta-induced phosphorylation of Sp1 and p107 repressor release have a critical role in histone deacetylase inhibitor-mediated derepression [corrected] of transcription of the luteinizing hormone receptor gene. Mol Cell Biol. 2006 Sep;26(18):6748-61.
REF 28 Angiotensin II-inducible platelet-derived growth factor-D transcription requires specific Ser/Thr residues in the second zinc finger region of Sp1. Circ Res. 2008 Feb 29;102(4):e38-51.
REF 29 Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Mol Cell. 2001 Oct;8(4):771-80.
REF 30 KIBRA is a novel substrate for protein kinase Czeta. Biochem Biophys Res Commun. 2004 May 7;317(3):703-7.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.