Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T59102 | Target Info | |||
| Target Name | Platelet-derived growth factor receptor beta (PDGFRB) | ||||
| Synonyms | Platelet-derived growth factor receptor 1; PDGFR1; PDGFR-beta; PDGFR-1; PDGFR; PDGF-R-beta; CD140b antigen; CD140b; CD140 antigen-like family member B; Beta-type platelet-derived growth factor receptor; Beta-PDGFR; Beta platelet-derived growth factor receptor | ||||
| Target Type | Successful Target | ||||
| Gene Name | PDGFRB | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Adapter proteins | [+] 1 Adapter proteins | + | |||
| Interacting Protein Name | Growth factor receptor-bound protein 2 (GRB2) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Reconstituted Complex | [2] | |||
| Ester hydrolases | [+] 1 Ester hydrolases | + | |||
| Interacting Protein Name | Phospholipase C-gamma-1 (PLCG1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | NCKAP3; PLC.II; PLC1; PLC148; PLCgamma1 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [3] | |||
| 2 | Affinity Capture-Western | [4] | |||
| 3 | Protein-peptide | [5] | |||
| Kinases | [+] 2 Kinases | + | |||
| Interacting Protein Name | Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | AGM7; GRB1; IMD36; p85; p85.ALPHA | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [6] | |||
| 2 | Affinity Capture-Western | [7] | |||
| 3 | Affinity Capture-Western | [8] | |||
| Interacting Target Name | Platelet-derived growth factor receptor alpha (PDGFRA) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | RHEPDGFRA; Platelet-derived growth factor receptor 2; Platelet-derived growth factor alpha receptor; PDGF-R-alpha; PDGFR-alpha; PDGFR-2; PDGFR2; CD140a antigen; CD140a; CD140 antigen-like family member A; Alpha-type platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [9] | |||
| 2 | Reconstituted Complex | [10] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck. J Biol Chem. 1999 Feb 26;274(9):5542-9. | ||||
| REF 2 | Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation. Mol Cell Biol. 1994 Oct;14(10):6715-26. | ||||
| REF 3 | Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase C gamma 1. Mol Biol Cell. 1993 Jan;4(1):49-57. | ||||
| REF 4 | FGF signal transduction in PC12 cells: comparison of the responses induced by endogenous and chimeric receptors. Immunol Cell Biol. 1998 Oct;76(5):406-13. | ||||
| REF 5 | SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome. Cell Commun Signal. 2012 Sep 14;10(1):27. | ||||
| REF 6 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 7 | GM1 inhibits early signaling events mediated by PDGF receptor in cultured human glioma cells. Anticancer Res. 1999 Nov-Dec;19(6B):5007-13. | ||||
| REF 8 | The p85alpha subunit of phosphatidylinositol 3'-kinase binds to and stimulates the GTPase activity of Rab proteins. J Biol Chem. 2004 Nov 19;279(47):48607-14. | ||||
| REF 9 | A unique autophosphorylation site in the platelet-derived growth factor alpha receptor from a heterodimeric receptor complex. Eur J Biochem. 1994 Oct 1;225(1):29-41. | ||||
| REF 10 | Two different subunits associate to create isoform-specific platelet-derived growth factor receptors. J Biol Chem. 1989 May 25;264(15):8771-8. | ||||
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