Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T58454 Target Info
Target Name Fibroblast growth factor receptor 2 (FGFR2)
Synonyms Keratinocyte growth factor receptor 2; Keratinocyte growth factor receptor; KSAM; KGFR; K-sam; FGFR-2; FGF-2 receptor; CD332; BEK
Target Type Successful Target
Gene Name FGFR2
Biochemical Class Kinase
UniProt ID
FGFR2_HUMAN 
Target Interacting Proteins  Top
Alpha-type channels [+] 1 Alpha-type channels +
Interacting Target Name Fibroblast growth factor-2 (FGF2) Successful Target Interacting Protein Info
UniProt ID
FGF2_HUMAN 
Synonyms Prostatropin; Heparin-binding growth factor 2; HBGF-2; Fibroblast growth factor 2; FGFB; FGF-2; BFGF; Basic fibroblast growth factor
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Protein-peptide [2]
3 Reconstituted Complex [3]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name Phospholipase C-gamma-1 (PLCG1) Interacting Protein Interacting Protein Info
UniProt ID
PLCG1_HUMAN 
Synonyms NCKAP3; PLC.II; PLC1; PLC148; PLCgamma1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Co-localization [5]
Growth factors [+] 4 Growth factors +
Interacting Target Name Heparin-binding growth factor 1 (FGF1) Clinical trial Target Interacting Protein Info
UniProt ID
FGF1_HUMAN 
Synonyms HBGF-1; Fibroblast growth factor 1; FGFA; FGF-1; Endothelial cell growth factor; ECGF-beta; ECGF; Beta-endothelial cell growth factor; AFGF; Acidic fibroblast growth factor
Evidence Score (E-score) 5 Experimental Evidences +
1 Co-localization [5]
2 Protein-peptide [2]
3 Reconstituted Complex [6]
4 Reconstituted Complex [3]
5 Reconstituted Complex [7]
Interacting Target Name Fibroblast growth factor-10 (FGF10) Discontinued Target Interacting Protein Info
UniProt ID
FGF10_HUMAN 
Synonyms Fibroblast growth factor 10; FGF10
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-localization [5]
2 Protein-peptide [2]
3 Reconstituted Complex [8]
Interacting Target Name Fibroblast growth factor-8 (FGF8) Literature-reported Target Interacting Protein Info
UniProt ID
FGF8_HUMAN 
Synonyms Heparin-binding growth factor 8; HBGF-8; Fibroblast growth factor 8; FGF-8; Androgen-induced growth factor; AIGF
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [5]
2 Protein-peptide [2]
Interacting Protein Name Fibroblast growth factor 5 (FGF5) Interacting Protein Interacting Protein Info
UniProt ID
FGF5_HUMAN 
Synonyms HBGF.5; Smag.82; TCMGLY
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [5]
2 Protein-peptide [2]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 Fibroblast growth factor-derived peptides: functional agonists of the fibroblast growth factor receptor. J Neurochem. 2008 Feb;104(3):667-82.
REF 3 Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. EMBO J. 1990 Sep;9(9):2685-92.
REF 4 Tyrosine 769 of the keratinocyte growth factor receptor is required for receptor signaling but not endocytosis. Biochem Biophys Res Commun. 2005 Feb 11;327(2):523-32.
REF 5 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 6 Expression and biological activity of mouse fibroblast growth factor-9. J Biol Chem. 1996 Jan 19;271(3):1726-31.
REF 7 Conservation of ligand specificity between the mammalian and amphibian fibroblast growth factor receptors. J Biol Chem. 1995 Dec 1;270(48):29018-24.
REF 8 Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7). J Biol Chem. 1998 May 22;273(21):13230-5.

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