Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T55986 Target Info
Target Name Proteasome beta-2 (PS beta-2)
Synonyms Proteasome subunit beta type-7; Proteasome subunit Z; Multicatalytic endopeptidase complex chain Z; Macropain chain Z
Target Type Patented-recorded Target
Gene Name PSMB7
Biochemical Class Peptidase
UniProt ID
PSB7_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Renal carcinoma antigen NY-REN-54 (UBE3A) Literature-reported Target Interacting Protein Info
UniProt ID
UBE3A_HUMAN 
Synonyms Ubiquitin-protein ligase E3A; Oncogenic protein-associated protein E6-AP; Human papillomavirus E6-associated protein; HPVE6A; HECT-type ubiquitin transferase E3A; EPVE6AP; E6AP ubiquitin-protein ligase; E6AP
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [1]
Peptidases [+] 13 Peptidases +
Interacting Protein Name Proteasome subunit alpha type-4 (PSMA4) Interacting Protein Interacting Protein Info
UniProt ID
PSA4_HUMAN 
Synonyms HC9; HsT17706; PSC9
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [4]
4 Affinity Capture-Western [5]
5 Co-fractionation [6]
6 Co-fractionation [7]
Interacting Protein Name Proteasome subunit beta type-3 (PSMB3) Interacting Protein Interacting Protein Info
UniProt ID
PSB3_HUMAN 
Synonyms HC10.II
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Co-fractionation [6]
3 Co-fractionation [7]
4 Reconstituted Complex [8]
5 Yeast two hybrid [9]
6 Yeast two hybrid [10]
Interacting Target Name Proteasome beta-5 (PS beta-5) Patented-recorded Target Interacting Protein Info
UniProt ID
PSB5_HUMAN 
Synonyms Proteasome subunit X; Proteasome subunit MB1; Proteasome subunit beta type-5; Proteasome epsilon chain; Proteasome chain 6; Multicatalytic endopeptidase complex epsilon chain; MB1; Macropain epsilon chain; LMPX
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Co-fractionation [6]
4 Co-fractionation [7]
5 Yeast two hybrid [9]
Interacting Target Name Proteasome beta-1 (PS beta-1) Patented-recorded Target Interacting Protein Info
UniProt ID
PSB6_HUMAN 
Synonyms Proteasome subunit Y; Proteasome subunit beta type-6; Proteasome delta chain; Multicatalytic endopeptidase complex delta chain; Macropain delta chain; LMPY
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Co-fractionation [6]
4 Co-fractionation [7]
5 Yeast two hybrid [10]
Interacting Protein Name Proteasome subunit beta type-1 (PSMB1) Interacting Protein Interacting Protein Info
UniProt ID
PSB1_HUMAN 
Synonyms HC5; PMSB1; PSC5
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-MS [3]
3 Co-fractionation [6]
4 Reconstituted Complex [8]
5 Yeast two hybrid [10]
Interacting Target Name Proteasome beta-9 (PS beta-9) Patented-recorded Target Interacting Protein Info
UniProt ID
PSB9_HUMAN 
Synonyms RING12; Really interesting new gene 12 protein; PSMB6i; Proteasome subunit beta-1i; Proteasome subunit beta type-9; Proteasome chain 7; Multicatalytic endopeptidase complex chain 7; Macropain chain 7; Low molecular mass protein 2; LMP2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [4]
4 Yeast two hybrid [10]
Interacting Protein Name Proteasome subunit alpha type-2 (PSMA2) Interacting Protein Interacting Protein Info
UniProt ID
PSA2_HUMAN 
Synonyms HC3; MU; PMSA2; PSC2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Co-fractionation [6]
4 Co-fractionation [7]
Interacting Protein Name Proteasome subunit alpha type-5 (PSMA5) Interacting Protein Interacting Protein Info
UniProt ID
PSA5_HUMAN 
Synonyms PSC5; ZETA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Co-fractionation [6]
4 Co-fractionation [7]
Interacting Target Name Proteasome beta-8 (PS beta-8) Clinical trial Target Interacting Protein Info
UniProt ID
PSB8_HUMAN 
Synonyms Y2; RING10; Really interesting new gene 10 protein; PSMB5i; Proteasome subunit beta-5i; Proteasome subunit beta type-8; Proteasome component C13; Multicatalytic endopeptidase complex subunit C13; Macropain subunit C13; Low molecular mass protein 7; LMP7
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Co-fractionation [7]
3 Co-fractionation [11]
Interacting Protein Name Proteasome subunit alpha type-3 (PSMA3) Interacting Protein Interacting Protein Info
UniProt ID
PSA3_HUMAN 
Synonyms HC8; PSC3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Co-fractionation [7]
Interacting Protein Name Proteasome subunit beta type-2 (PSMB2) Interacting Protein Interacting Protein Info
UniProt ID
PSB2_HUMAN 
Synonyms HC7.I
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Co-fractionation [6]
3 Co-fractionation [7]
Interacting Protein Name Proteasome subunit alpha-type 8 (PSMA8) Interacting Protein Interacting Protein Info
UniProt ID
PSMA8_HUMAN 
Synonyms PSMA7L
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Yeast two hybrid [10]
Interacting Target Name Ubiquitin C-terminal hydrolase UCH37 (UCHL5) Patented-recorded Target Interacting Protein Info
UniProt ID
UCHL5_HUMAN 
Synonyms UCH-L5; UCH37; Ubiquitin thioesterase L5; Ubiquitin carboxyl-terminal hydrolase isozyme L5; CGI-70; AD-019
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Co-fractionation [7]
Proteasome components [+] 4 Proteasome components +
Interacting Protein Name Proteasome 26S subunit non-ATPase 11 (PSMD11) Interacting Protein Interacting Protein Info
UniProt ID
PSD11_HUMAN 
Synonyms Rpn6; S9; p44.5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Co-fractionation [11]
Interacting Protein Name Proteasome 26S subunit non-ATPase 12 (PSMD12) Interacting Protein Interacting Protein Info
UniProt ID
PSD12_HUMAN 
Synonyms Rpn5; p55
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Co-fractionation [7]
3 Co-fractionation [11]
Interacting Protein Name Proteasome 26S subunit non-ATPase 1 (PSMD1) Interacting Protein Interacting Protein Info
UniProt ID
PSMD1_HUMAN 
Synonyms P112; Rpn2; S1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Co-fractionation [11]
Interacting Protein Name Proteasome 26S subunit non-ATPase 3 (PSMD3) Interacting Protein Interacting Protein Info
UniProt ID
PSMD3_HUMAN 
Synonyms P58; RPN3; S3; TSTA2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Co-fractionation [11]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Proteasome maturation protein (POMP) Interacting Protein Interacting Protein Info
UniProt ID
POMP_HUMAN 
Synonyms C13orf12; PNAS.110; UMP1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Yeast two hybrid [9]
4 Yeast two hybrid [10]
References  Top
REF 1 Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes. Mol Cell Biol. 2012 Aug;32(15):3095-106.
REF 2 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 3 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 4 Tumor cell lines expressing the proteasome subunit isoform LMP7E1 exhibit immunoproteasome deficiency. Cancer Res. 2006 Jan 15;66(2):649-52.
REF 5 Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress. Cell. 2010 Aug 20;142(4):613-24.
REF 6 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 7 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 8 Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome. Mol Cell Proteomics. 2017 May;16(5):840-854.
REF 9 Protein-protein interactions among human 20S proteasome subunits and proteassemblin. Biochem Biophys Res Commun. 2004 Feb 6;314(2):523-8.
REF 10 The proteasome maturation protein POMP facilitates major steps of 20S proteasome formation at the endoplasmic reticulum. EMBO Rep. 2007 Dec;8(12):1170-5.
REF 11 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 12 Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. Mol Cell. 2008 Sep 26;31(6):909-17.

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