Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T54761 Target Info
Target Name Myelin basic protein (MBP)
Synonyms Myelin membrane encephalitogenic protein; Myelin A1 protein
Target Type Clinical trial Target
Gene Name MBP
UniProt ID
MBP_HUMAN 
Target Interacting Proteins  Top
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name Nuclear LIM interactor-interacting factor 3 (CTDSP1) Interacting Protein Interacting Protein Info
UniProt ID
CTDS1_HUMAN 
Synonyms NIF3; NLI.IF; NLIIF; SCP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [2]
Kinases [+] 1 Kinases +
Interacting Target Name Extracellular signal-regulated kinase 2 (ERK2) Clinical trial Target Interacting Protein Info
UniProt ID
MK01_HUMAN 
Synonyms PRKM2; PRKM1; P42-MAPK; P42 Mitogen-activated protein kinase; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 1; MAPK 2; MAPK 1; MAP kinase isoform p42; MAP kinase 2; MAP kinase 1; ERT1; ERK-2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Biochemical Activity [4]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Myelin proteolipid protein (PLP1) Interacting Protein Interacting Protein Info
UniProt ID
MYPR_HUMAN 
Synonyms GPM6C; HLD1; MMPL; PLP; PLP/DM20; PMD; SPG2
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-purification [5]
2 Reconstituted Complex [6]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 3 G protein-coupled receptor-mediated mitogen-activated protein kinase activation through cooperation of Galpha(q) and Galpha(i) signals. Mol Cell Biol. 2000 Sep;20(18):6837-48.
REF 4 The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol. 2007 Nov;9(11):1243-52.
REF 5 Interaction between human myelin basic protein and lipophilin. Neurochem Res. 1984 Oct;9(10):1523-31.
REF 6 Interaction of myelin basic protein and proteolipid protein. J Neurosci Res. 1989 Jan;22(1):97-102.

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