Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T53251 | Target Info | |||
| Target Name | Histone-lysine N-methyltransferase EHMT2 (EHMT2) | ||||
| Synonyms | Protein G9a; NG36; Lysine N-methyltransferase 1C; KMT1C; Histone H3-K9 methyltransferase 3; HLA-B-associated transcript 8; H3-K9-HMTase 3; G9A; Euchromatic histone-lysine N-methyltransferase 2; C6orf30; BAT8 | ||||
| Target Type | Preclinical Target | ||||
| Gene Name | EHMT2 | ||||
| Biochemical Class | Methyltransferase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acyltransferases | [+] 1 Acyltransferases | + | |||
| Interacting Protein Name | E3 ubiquitin-protein ligase UHRF1 (UHRF1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | ICBP90; Np95; RNF106; hNP95; hUHRF1; huNp95 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Co-localization | [3] | |||
| One-carbon transferases | [+] 2 One-carbon transferases | + | |||
| Interacting Target Name | DNA [cytosine-5]-methyltransferase 1 (DNMT1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | MCMT; M.HsaI; Dnmt1; DNMT; DNA MTase HsaI; DNA methyltransferase HsaI; DNA (cytosine-5)-methyltransferase 1; DNA (cytosine5)methyltransferase 1; CXXC-type zinc finger protein 9; CXXCtype zinc finger protein 9; CXXC9; AIM | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [4] | |||
| 2 | Affinity Capture-Western | [5] | |||
| Interacting Target Name | Euchromatic histone-lysine N-methyltransferase 1 (EHMT1) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | EHMT1 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [6] | |||
| 2 | Affinity Capture-MS | [7] | |||
| Transcription regulators | [+] 1 Transcription regulators | + | |||
| Interacting Protein Name | Protein Wiz (WIZ) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | ZNF803 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [6] | |||
| 2 | Affinity Capture-MS | [7] | |||
| 3 | Affinity Capture-Western | [8] | |||
| Other proteins | [+] 3 Other proteins | + | |||
| Interacting Protein Name | Chromobox protein homolog 1 (CBX1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CBX; HP1.BETA; HP1Hs.beta; HP1Hsbeta; M31; MOD1; p25beta | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [9] | |||
| 2 | Reconstituted Complex | [10] | |||
| 3 | Reconstituted Complex | [11] | |||
| Interacting Protein Name | Chromobox protein homolog 3 (CBX3) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | HECH; HP1.GAMMA; HP1Hs.gamma | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [9] | |||
| 2 | Co-localization | [11] | |||
| 3 | Reconstituted Complex | [11] | |||
| Interacting Protein Name | Chromobox protein homolog 5 (CBX5) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | HEL25; HP1; HP1A | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [9] | |||
| 2 | Co-localization | [11] | |||
| 3 | Reconstituted Complex | [11] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. Nucleic Acids Res. 2009 Feb;37(2):493-505. | ||||
| REF 2 | S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance. Cell Res. 2011 Dec;21(12):1723-39. | ||||
| REF 3 | UHRF1 is associated with epigenetic silencing of BRCA1 in sporadic breast cancer. Breast Cancer Res Treat. 2010 Sep;123(2):359-73. | ||||
| REF 4 | The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes. Oncogene. 2014 Apr 24;33(17):2157-68. | ||||
| REF 5 | Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication. Genes Dev. 2006 Nov 15;20(22):3089-103. | ||||
| REF 6 | Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol. 2011 Mar;29(3):255-65. | ||||
| REF 7 | A High-Density Map for Navigating the Human Polycomb Complexome. Cell Rep. 2016 Oct 4;17(2):583-595. | ||||
| REF 8 | Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. J Biol Chem. 2006 Jul 21;281(29):20120-8. | ||||
| REF 9 | Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes. Mol Cell. 2004 Jun 18;14(6):727-38. | ||||
| REF 10 | Identification and characterization of posttranslational modification-specific binding proteins in vivo by mammalian tethered catalysis. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14808-13. | ||||
| REF 11 | Automethylation of G9a and its implication in wider substrate specificity and HP1 binding. Nucleic Acids Res. 2007;35(21):7313-23. | ||||
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