Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T46781 Target Info
Target Name Aurora kinase B (AURKB)
Synonyms Serine/threonine-protein kinase aurora-B; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase 12; Serine/threonine protein kinase 12; STK5; STK12; Aurora/IPL1-related kinase 2; Aurora-related kinase 2; Aurora-B; Aurora-2 kinase; Aurora-2; Aurora- and Ipl1-like midbody-associated protein 1; Aurora 1; ARK2; ARK-2; AIRK2; AIM1; AIM-1; AIK2
Target Type Clinical trial Target
Gene Name AURKB
Biochemical Class Kinase
UniProt ID
AURKB_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Kinesin-like protein KIF20A (KIF20A) Interacting Protein Interacting Protein Info
UniProt ID
KI20A_HUMAN 
Synonyms MKLP2; RAB6KIFL
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [1]
2 Reconstituted Complex [2]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
Histones [+] 1 Histones +
Interacting Protein Name Histone H3.1 (H31) Interacting Protein Interacting Protein Info
UniProt ID
H31_HUMAN 
Synonyms H3/A; H3FA
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [5]
2 Reconstituted Complex [5]
Peptidases [+] 1 Peptidases +
Interacting Protein Name Proteasome subunit alpha type-3 (PSMA3) Interacting Protein Interacting Protein Info
UniProt ID
PSA3_HUMAN 
Synonyms HC8; PSC3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Yeast two hybrid [6]
Other proteins [+] 3 Other proteins +
Interacting Target Name Apoptosis inhibitor survivin (BIRC5) Clinical trial Target Interacting Protein Info
UniProt ID
BIRC5_HUMAN 
Synonyms Survivin; IAP4; Baculoviral IAP repeat-containing protein 5; Apoptosis inhibitor survivin; Apoptosis inhibitor 4; API4
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Co-localization [8]
3 Reconstituted Complex [9]
4 Yeast two hybrid [10]
Interacting Target Name Borealin (CDCA8) Literature-reported Target Interacting Protein Info
UniProt ID
BOREA_HUMAN 
Synonyms Pluripotent embryonic stem cell-related gene 3 protein; Pluripotent embryonic stem cellrelated gene 3 protein; PESCRG3; hDasra-B; hDasraB; Dasra-B; DasraB; Dasra B; Cell division cycle-associated protein 8; Cell division cycleassociated protein 8
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Biochemical Activity [12]
3 Co-localization [8]
4 Reconstituted Complex [9]
Interacting Protein Name Inner centromere protein (INCENP) Interacting Protein Interacting Protein Info
UniProt ID
INCE_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [12]
2 Reconstituted Complex [9]
3 Yeast two hybrid [13]
References  Top
REF 1 Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules. Dev Cell. 2016 Jan 11;36(1):63-78.
REF 2 Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. J Cell Biol. 2004 Jul 19;166(2):167-72.
REF 3 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 4 Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell. 2012 Aug 31;150(5):987-1001.
REF 5 Methylation-mediated control of aurora kinase B and Haspin with epigenetically modified histone H3 N-terminal peptides. Bioorg Med Chem. 2011 Apr 1;19(7):2373-7.
REF 6 Human aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner. Mol Cell Biochem. 2003 Dec;254(1-2):157-62.
REF 7 The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. J Cell Biol. 2009 Dec 14;187(6):791-800.
REF 8 INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. J Cell Biol. 2009 Nov 30;187(5):637-53.
REF 9 Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis. Genes Cells. 2011 Jun;16(6):652-69.
REF 10 INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosis. Curr Biol. 2001 Jun 5;11(11):886-90.
REF 11 Regulation of aurora B kinase by the lipid raft protein flotillin-1. J Biol Chem. 2010 Jul 2;285(27):20683-90.
REF 12 Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle. J Cell Biol. 2004 Jul 19;166(2):179-91.
REF 13 Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP. Mol Biol Cell. 2006 Jun;17(6):2547-58.

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