Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T45591 Target Info
Target Name Nucleophosmin (NPM1)
Synonyms Numatrin; Nucleolar protein NO38; Nucleolar phosphoprotein B23; NPM
Target Type Clinical trial Target
Gene Name NPM1
UniProt ID
NPM_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Protein Name Nucleolar RNA helicase 2 (DDX21) Interacting Protein Interacting Protein Info
UniProt ID
DDX21_HUMAN 
Synonyms GUA; GURDB; RH.II/GU; RH.II/GuA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
Interacting Protein Name Proteasome 26S subunit ATPase 4 (PSMC4) Interacting Protein Interacting Protein Info
UniProt ID
PRS6B_HUMAN 
Synonyms MIP224; RPT3; S6; TBP.7; TBP7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Yeast two hybrid [5]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Reconstituted Complex [7]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name Multiple tumor suppressor 1 (CDKN2A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN2A_HUMAN 
Synonyms Tumour suppressor gene p16; P16-INK4a; p16INK4A; P16-INK4; P16 gene; MTS-1; Cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; CDK4I
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Affinity Capture-Western [9]
3 Affinity Capture-Western [10]
4 Reconstituted Complex [11]
Histones [+] 6 Histones +
Interacting Protein Name Histone H3.1 (H31) Interacting Protein Interacting Protein Info
UniProt ID
H31_HUMAN 
Synonyms H3/A; H3FA
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [12]
4 Reconstituted Complex [13]
Interacting Protein Name Histone H4 (H4) Interacting Protein Interacting Protein Info
UniProt ID
H4_HUMAN 
Synonyms H4FA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [12]
2 Affinity Capture-Western [12]
3 Reconstituted Complex [13]
Interacting Target Name Gamma-Histone H2AX (H2AFX) Literature-reported Target Interacting Protein Info
UniProt ID
H2AX_HUMAN 
Synonyms Phosphorylation of H2AX; Histone H2AX; Histone H2A.x; H2AX; H2a/x
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-Western [14]
Interacting Protein Name Histone H1.2 (HIST1H1C) Interacting Protein Interacting Protein Info
UniProt ID
H12_HUMAN 
Synonyms H1.2; H1C; H1F2; H1s.1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [15]
Interacting Protein Name Histone H1x (H1FX) Interacting Protein Interacting Protein Info
UniProt ID
H1X_HUMAN 
Synonyms H1.10; H1X
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [15]
Interacting Protein Name Histone H2B type 2-E (HIST2H2BE) Interacting Protein Interacting Protein Info
UniProt ID
H2B2E_HUMAN 
Synonyms GL105; H2B; H2B.1; H2BFQ; H2BGL105; H2BQ
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Reconstituted Complex [13]
Kinases [+] 2 Kinases +
Interacting Target Name Protein kinase C zeta (PRKCZ) Patented-recorded Target Interacting Protein Info
UniProt ID
KPCZ_HUMAN 
Synonyms Protein kinase C zeta type; PKC2; NPKC-zeta
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-Western [4]
Interacting Target Name Tyrosine-protein kinase EIF2AK2 (p68) Patented-recorded Target Interacting Protein Info
UniProt ID
E2AK2_HUMAN 
Synonyms Proteinkinase RNA-activated; Protein kinase RNA-activated; Protein kinase R; PRKR; PKR; p68 kinase; P1/eIF-2A protein kinase; Interferon-inducible RNA-dependent protein kinase; Interferon-induced, double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [17]
2 Reconstituted Complex [18]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [19]
2 Affinity Capture-Western [19]
3 Reconstituted Complex [20]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Target Name Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Clinical trial Target Interacting Protein Info
UniProt ID
G3P_HUMAN 
Synonyms Peptidyl-cysteine S-nitrosylase GAPDH; OK/SW-cl.12; GAPD; D-glyceraldehyde-3-phosphate dehydrogenase; CDABP0047
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [21]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [22]
2 Affinity Capture-Western [23]
3 Affinity Capture-Western [24]
4 Reconstituted Complex [25]
5 Reconstituted Complex [22]
Ribosomal proteins [+] 6 Ribosomal proteins +
Interacting Protein Name Large ribosomal subunit protein uL18 (RPL5) Interacting Protein Interacting Protein Info
UniProt ID
RL5_HUMAN 
Synonyms DBA6; L5; PPP1R135
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [15]
3 Affinity Capture-Western [26]
Interacting Protein Name Large ribosomal subunit protein eL14 (RPL14) Interacting Protein Interacting Protein Info
UniProt ID
RL14_HUMAN 
Synonyms CAG.ISL.7; CTG.B33; L14; RL14; hRL14
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Co-fractionation [27]
Interacting Protein Name Large ribosomal subunit protein eL24 (RPL24) Interacting Protein Interacting Protein Info
UniProt ID
RL24_HUMAN 
Synonyms HEL.S.310; L24
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Co-fractionation [27]
Interacting Protein Name Large ribosomal subunit protein eL6 (RPL6) Interacting Protein Interacting Protein Info
UniProt ID
RL6_HUMAN 
Synonyms L6; SHUJUN.2; TAXREB107; TXREB1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Co-fractionation [27]
Interacting Protein Name Single copy abundant protein (RPS4X) Interacting Protein Interacting Protein Info
UniProt ID
RS4X_HUMAN 
Synonyms CCG2; DXS306; RPS4; S4; SCAR; SCR10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Co-fractionation [27]
Interacting Protein Name Small ribosomal subunit protein eS6 (RPS6) Interacting Protein Interacting Protein Info
UniProt ID
RS6_HUMAN 
Synonyms S6
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Co-fractionation [27]
Transcription regulators [+] 5 Transcription regulators +
Interacting Target Name AP-2 transcription factor (TFAP2A) Literature-reported Target Interacting Protein Info
UniProt ID
AP2A_HUMAN 
Synonyms Transcription factor AP-2-alpha; TFAP2; AP2TF; AP2-alpha; AP-2; Activator protein 2; Activating enhancer-binding protein 2-alpha
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Co-localization [28]
3 Reconstituted Complex [28]
4 Yeast two hybrid [29]
Interacting Protein Name Proliferation-associated protein 2G4 (PA2G4) Interacting Protein Interacting Protein Info
UniProt ID
PA2G4_HUMAN 
Synonyms EBP1; HG4.1; p38.2G4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [15]
2 Affinity Capture-Western [30]
3 Reconstituted Complex [30]
Interacting Protein Name Nuclease-sensitive element-binding protein 1 (YBX1) Interacting Protein Interacting Protein Info
UniProt ID
YBOX1_HUMAN 
Synonyms BP.8; CSDA2; CSDB; DBPB; MDR.NF1; NSEP.1; NSEP1; YB.1; YB1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [4]
Interacting Protein Name Zinc finger protein 668 (ZNF668) Interacting Protein Interacting Protein Info
UniProt ID
ZN668_HUMAN 
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [31]
Interacting Protein Name Transcription factor p65 (RELA) Interacting Protein Interacting Protein Info
UniProt ID
TF65_HUMAN 
Synonyms NFKB3; p65
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [29]
2 Yeast two hybrid [5]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Ubiquitin-protein ligase E3 Mdm2 (MDM2) Clinical trial Target Interacting Protein Info
UniProt ID
MDM2_HUMAN 
Synonyms RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [32]
2 Reconstituted Complex [23]
Other proteins [+] 4 Other proteins +
Interacting Protein Name Nucleoplasmin-3 (NPM3) Interacting Protein Interacting Protein Info
UniProt ID
NPM3_HUMAN 
Synonyms PORMIN; TMEM123
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [15]
5 Affinity Capture-Western [33]
Interacting Target Name Nucleolin (NCL) Clinical trial Target Interacting Protein Info
UniProt ID
NUCL_HUMAN 
Synonyms Protein C23; Nucleolin
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [26]
4 Co-fractionation [27]
Interacting Protein Name Heterogeneous nuclear ribonucleoprotein U (HNRNPU) Interacting Protein Interacting Protein Info
UniProt ID
HNRPU_HUMAN 
Synonyms HNRPU; SAF.A; U21.1; hnRNP U
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [15]
Interacting Protein Name Mitochondrial hinge protein (UQCRH) Interacting Protein Interacting Protein Info
UniProt ID
QCR6_HUMAN 
Synonyms QCR6; UQCR8
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Yeast two hybrid [5]
References  Top
REF 1 Characterization of the DOT1L network: implications of diverse roles for DOT1L. Protein J. 2010 Apr;29(3):213-23.
REF 2 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 3 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 4 Quantitative study of the interactome of PKC involved in the EGF-induced tumor cell chemotaxis. J Proteome Res. 2013 Mar 1;12(3):1478-86.
REF 5 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 6 Identification of NPM-ALK interacting proteins by tandem mass spectrometry. Oncogene. 2004 Apr 8;23(15):2617-29.
REF 7 Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity. Mol Cell Biol. 1998 Dec;18(12):6951-61.
REF 8 The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing. EMBO Rep. 2008 Mar;9(3):273-9.
REF 9 Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF. Oncogene. 2015 Mar 26;34(13):1688-97.
REF 10 Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability. J Biol Chem. 2006 Jul 7;281(27):18463-72.
REF 11 Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun. 2015 Jan 20;6:5909.
REF 12 HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1349-54.
REF 13 Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription. Mol Cell Biol. 2005 Sep;25(17):7534-45.
REF 14 The dynamic alterations of H2AX complex during DNA repair detected by a proteomic approach reveal the critical roles of Ca(2+)/calmodulin in the ionizing radiation-induced cell cycle arrest. Mol Cell Proteomics. 2006 Jun;5(6):1033-44.
REF 15 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 16 Profiling the interactome of protein kinase C by proteomics and bioinformatics. Proteome Sci. 2018 Feb 26;16:5.
REF 17 Antiviral action of the tumor suppressor ARF. EMBO J. 2006 Sep 20;25(18):4284-92.
REF 18 Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR. J Biol Chem. 2003 Oct 24;278(43):41709-17.
REF 19 Identification of a hormone-regulated dynamic nuclear actin network associated with estrogen receptor alpha in human breast cancer cell nuclei. Mol Cell Proteomics. 2010 Jun;9(6):1352-67.
REF 20 Proteomics analysis of the estrogen receptor alpha receptosome. Mol Cell Proteomics. 2010 Jul;9(7):1411-22.
REF 21 S-nitrosylation of B23/nucleophosmin by GAPDH protects cells from the SIAH1-GAPDH death cascade. J Cell Biol. 2012 Oct 1;199(1):65-76.
REF 22 Nucleophosmin regulates the stability and transcriptional activity of p53. Nat Cell Biol. 2002 Jul;4(7):529-33.
REF 23 Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation. Cancer Cell. 2004 May;5(5):465-75.
REF 24 Negative regulation of p53 by nucleophosmin antagonizes stress-induced apoptosis in human normal and malignant hematopoietic cells. Leuk Res. 2005 Dec;29(12):1415-23.
REF 25 Characterisation of the interface between nucleophosmin (NPM) and p53: potential role in p53 stabilisation. FEBS Lett. 2006 Jan 9;580(1):345-50.
REF 26 Nucleophosmin is essential for ribosomal protein L5 nuclear export. Mol Cell Biol. 2006 May;26(10):3798-809.
REF 27 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 28 Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation. EMBO Rep. 2007 Apr;8(4):394-400.
REF 29 Mutations in the SOD2 promoter reveal a molecular basis for an activating protein 2-dependent dysregulation of manganese superoxide dismutase expression in cancer cells. Mol Cancer Res. 2008 Dec;6(12):1881-93.
REF 30 Ebp1 association with nucleophosmin/B23 is essential for regulating cell proliferation and suppressing apoptosis. J Biol Chem. 2007 Dec 14;282(50):36744-54.
REF 31 ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. Cancer Res. 2011 Oct 15;71(20):6524-34.
REF 32 An iTRAQ proteomics screen reveals the effects of the MDM2 binding ligand Nutlin-3 on cellular proteostasis. J Proteome Res. 2012 Nov 2;11(11):5464-78.
REF 33 Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling. Nucleic Acids Res. 2012 Jun;40(11):4861-78.

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