Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T42854 | Target Info | |||
| Target Name | Melanoma-associated antigen 1 (MAGEA1) | ||||
| Synonyms | Melanomaassociated antigen 1; MAGE1A; MAGE1 antigen; MAGE1; MAGE-1 antigen; Cancer/testis antigen 1.1; CT1.1; Antigen MZ2E; Antigen MZ2-E | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | MAGEA1 | ||||
| Biochemical Class | Melanoma associated antigen | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acyltransferases | [+] 1 Acyltransferases | + | |||
| Interacting Protein Name | E3 ubiquitin-protein ligase TRIM31 (TRIM31) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | C6orf13; HCG1; HCGI; RNF | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Yeast two hybrid | [1] | |||
| 3 | Yeast two hybrid | [2] | |||
| 4 | Yeast two hybrid | [3] | |||
| Transcription regulators | [+] 1 Transcription regulators | + | |||
| Interacting Protein Name | Pre-B-cell leukemia transcription factor 3 (PBX3) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [4] | |||
| 2 | Affinity Capture-MS | [5] | |||
| 3 | Yeast two hybrid | [2] | |||
| Other proteins | [+] 2 Other proteins | + | |||
| Interacting Protein Name | SNW domain-containing protein 1 (SNW1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Bx42; NCOA.62; PRPF45; Prp45; SKIIP; SKIP | ||||
| Evidence Score (E-score) | 5 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [6] | |||
| 2 | Affinity Capture-Western | [7] | |||
| 3 | Reconstituted Complex | [6] | |||
| 4 | Reconstituted Complex | [7] | |||
| 5 | Yeast two hybrid | [6] | |||
| Interacting Protein Name | Non-structural maintenance of chromosomes element 4 homolog A (NSMCE4A) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | C10orf86; NS4EA; NSE4A | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [8] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | The melanoma-associated antigen 1 (MAGEA1) protein stimulates the E3 ubiquitin-ligase activity of TRIM31 within a TRIM31-MAGEA1-NSE4 complex. Cell Cycle. 2015;14(6):920-30. | ||||
| REF 2 | A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226. | ||||
| REF 3 | Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8. | ||||
| REF 4 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 5 | The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440. | ||||
| REF 6 | MAGE-A1 interacts with adaptor SKIP and the deacetylase HDAC1 to repress transcription. Nucleic Acids Res. 2004 Aug 17;32(14):4340-50. | ||||
| REF 7 | MAGEA1 interacts with FBXW7 and regulates ubiquitin ligase-mediated turnover of NICD1 in breast and ovarian cancer cells. Oncogene. 2017 Aug 31;36(35):5023-5034. | ||||
| REF 8 | Interactions between the Nse3 and Nse4 components of the SMC5-6 complex identify evolutionarily conserved interactions between MAGE and EID Families. PLoS One. 2011 Feb 25;6(2):e17270. | ||||
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