Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T40474 Target Info
Target Name Proto-oncogene c-Met (MET)
Synonyms Tyrosine-protein kinase Met; Scatter factor receptor; SF receptor; Met proto-oncogene tyrosine kinase; Hepatocyte growth factor receptor; HGF/SF receptor; HGF-SF receptor; HGF receptor; C-met; C-Met receptor tyrosine kinase
Target Type Successful Target
Gene Name MET
Biochemical Class Kinase
UniProt ID
MET_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Signal transduction protein CBL (CBL) Literature-reported Target Interacting Protein Info
UniProt ID
CBL_HUMAN 
Synonyms RNF55; RING-type E3 ubiquitin transferase CBL; RING finger protein 55; Proto-oncogene c-CBL; E3 ubiquitin-protein ligase CBL; C-Cbl; CBL2; Casitas B-lineage lymphoma proto-oncogene
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Co-crystal Structure [2]
6 Reconstituted Complex [5]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [7]
Peptidases [+] 1 Peptidases +
Interacting Target Name Hepatocyte growth factor (HGF) Clinical trial Target Interacting Protein Info
UniProt ID
HGF_HUMAN 
Synonyms SF; Scatter factor; HPTA; Hepatopoietin-A; Hepatopoeitin A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Biochemical Activity [8]
3 Reconstituted Complex [8]
References  Top
REF 1 Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res. 2006 Jan 1;66(1):283-9.
REF 2 Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates. EMBO J. 2008 Mar 5;27(5):804-16.
REF 3 Phosphorylation of the MET receptor on juxtamembrane tyrosine residue 1001 inhibits its caspase-dependent cleavage. Cell Signal. 2009 Sep;21(9):1455-63.
REF 4 Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol. 2009 May 18;185(4):743-54.
REF 5 An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding. FEBS Lett. 2011 Jan 21;585(2):281-5.
REF 6 Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways. Invest Ophthalmol Vis Sci. 1998 Jul;39(8):1329-38.
REF 7 Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility. J Biol Chem. 1996 Jun 14;271(24):14119-23.
REF 8 Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. EXS. 1993;65:131-65.

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