Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T40016 Target Info
Target Name Glucocorticoid receptor (NR3C1)
Synonyms Nuclear receptor subfamily 3 group C member 1; GRL; GR
Target Type Successful Target
Gene Name NR3C1
Biochemical Class Nuclear hormone receptor
UniProt ID
GCR_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Target Name Mitotic growth and transcription activator (BAF190A) Literature-reported Target Interacting Protein Info
UniProt ID
SMCA4_HUMAN 
Synonyms Transcription activator BRG1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; SNF2L4; SNF2-beta; SNF2B; Protein BRG-1; Protein brahma homolog 1; BRG1-associated factor 190A; BRG1; ATP-dependent helicase SMARCA4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Proximity Label-MS [2]
3 Reconstituted Complex [3]
Acyltransferases [+] 2 Acyltransferases +
Interacting Target Name Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA3_HUMAN 
Synonyms TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Protein-peptide [4]
3 Proximity Label-MS [2]
4 Reconstituted Complex [5]
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Proximity Label-MS [2]
3 Reconstituted Complex [5]
Carbon-nitrogen hydrolases [+] 1 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Co-fractionation [8]
3 Fluorescence Resonance Energy Transfer [9]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Co-localization [11]
3 Protein-Fragment Complementation Assay [12]
4 Reconstituted Complex [13]
Isomerases [+] 1 Isomerases +
Interacting Target Name FK506-binding protein 4 (FKBP4) Literature-reported Target Interacting Protein Info
UniProt ID
FKBP4_HUMAN 
Synonyms PPIase FKBP4; Peptidyl-prolyl cis-trans isomerase FKBP4; P59 protein; p59; Immunophilin FKBP52; HSP-binding immunophilin; HSP binding immunophilin; HBI; FKBP59; FKBP52 protein; FKBP-52; FKBP52; FKBP-4; 59 kDa immunophilin; 52 kDa FKBP; 52 kDa FK506-binding protein; 52 kDa FK506 binding protein
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Reconstituted Complex [15]
Kinases [+] 1 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [16]
2 Protein-Fragment Complementation Assay [16]
3 Yeast two hybrid [17]
Mediator complexes [+] 1 Mediator complexes +
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 1 (MED1) Interacting Protein Interacting Protein Info
UniProt ID
MED1_HUMAN 
Synonyms CRSP1; CRSP200; DRIP205; DRIP230; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2
Evidence Score (E-score) 2 Experimental Evidences +
1 Proximity Label-MS [2]
2 Reconstituted Complex [5]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Orphan nuclear receptor DAX-1 (NR0B1) Literature-reported Target Interacting Protein Info
UniProt ID
NR0B1_HUMAN 
Synonyms Nuclear receptor subfamily 0 group B member 1; Nuclear receptor DAX-1; DSS-AHC critical region on the X chromosome protein 1; DAX1; AHC
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-Fragment Complementation Assay [12]
2 Protein-peptide [4]
Transcription regulators [+] 7 Transcription regulators +
Interacting Protein Name Nuclear receptor coactivator 2 (NCOA2) Interacting Protein Interacting Protein Info
UniProt ID
NCOA2_HUMAN 
Synonyms GRIP1; KAT13C; NCoA.2; SRC2; TIF2; bHLHe75
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Proximity Label-MS [2]
3 Reconstituted Complex [5]
4 Yeast two hybrid [18]
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 3 Experimental Evidences +
1 Proximity Label-MS [2]
2 Reconstituted Complex [19]
3 Yeast two hybrid [20]
Interacting Target Name Signal transducer and activator of transcription 3 (STAT3) Successful Target Interacting Protein Info
UniProt ID
STAT3_HUMAN 
Synonyms Transcription factor STAT3; Stat3; Signal transducer and activator of transcription 3; APRF; Acute-phase response factor
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Reconstituted Complex [22]
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [23]
Interacting Target Name DNA-binding factor KBF1 (p105) Clinical trial Target Interacting Protein Info
UniProt ID
NFKB1_HUMAN 
Synonyms Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; Nuclear factor of kappa light polypeptide gene enhancer in Bcells 1; Nuclear factor NFkappaB p50 subunit; Nuclear factor NF-kappa-B p105 subunit; Nuclear factor NFkappaB p105 subunit; EBP-1; EBP1; DNA-binding factor KBF1; DNAbinding factor KBF1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Reconstituted Complex [25]
Interacting Protein Name POU class 2 homeobox 1 (POU2F1) Interacting Protein Interacting Protein Info
UniProt ID
PO2F1_HUMAN 
Synonyms OCT1; OTF1; oct.1B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [26]
2 Reconstituted Complex [27]
Interacting Protein Name SWI/SNF complex subunit SMARCC1 (SMARCC1) Interacting Protein Interacting Protein Info
UniProt ID
SMRC1_HUMAN 
Synonyms BAF155; CRACC1; Rsc8; SRG3; SWI3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Proximity Label-MS [2]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Tumor susceptibility gene protein 101 (TSG101) Clinical trial Target Interacting Protein Info
UniProt ID
TS101_HUMAN 
Synonyms Tumor susceptibility gene 101 protein; ESCRT-I complex subunit TSG101
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [28]
2 Yeast two hybrid [29]
Other proteins [+] 5 Other proteins +
Interacting Target Name Thioredoxin (TXN) Clinical trial Target Interacting Protein Info
UniProt ID
THIO_HUMAN 
Synonyms TRX1; Trx; TRDX; Surface-associated sulphydryl protein; Surface associated sulphydryl protein; SASP; ATL-derived factor; ADF
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [30]
2 Yeast two hybrid [31]
Interacting Protein Name BAG family molecular chaperone regulator 1 (BAG1) Interacting Protein Interacting Protein Info
UniProt ID
BAG1_HUMAN 
Synonyms BAG.1; HAP; RAP46
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [32]
2 Reconstituted Complex [33]
Interacting Protein Name Nuclear receptor-interacting protein 1 (NRIP1) Interacting Protein Interacting Protein Info
UniProt ID
NRIP1_HUMAN 
Synonyms RIP140
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [34]
2 Reconstituted Complex [5]
Interacting Protein Name RNA-binding protein 14 (RBM14) Interacting Protein Interacting Protein Info
UniProt ID
RBM14_HUMAN 
Synonyms COAA; PSP2; SIP; SYTIP1; TMEM137
Evidence Score (E-score) 2 Experimental Evidences +
1 Proximity Label-MS [2]
2 Yeast two hybrid [35]
Interacting Protein Name Small integral membrane protein 40 (SMIM40) Interacting Protein Interacting Protein Info
UniProt ID
SIM40_HUMAN 
Synonyms BING2; DAP6; EAP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [36]
2 Affinity Capture-Western [37]
References  Top
REF 1 BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation. Mol Cell Biol. 2003 Sep;23(17):6210-20.
REF 2 Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping. Mol Cell Proteomics. 2017 Aug;16(8):1462-1474.
REF 3 Recruitment of the SWI-SNF chromatin remodeling complex as a mechanism of gene activation by the glucocorticoid receptor tau1 activation domain. Mol Cell Biol. 2000 Mar;20(6):2004-13.
REF 4 Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol. Mol Cell Biol. 2008 Mar;28(6):1915-23.
REF 5 Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140. Mol Endocrinol. 2001 Apr;15(4):501-11.
REF 6 Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex. Nature. 1998 May 7;393(6680):88-91.
REF 7 HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription. Mol Cell. 2006 Jun 9;22(5):669-79.
REF 8 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 9 Dynamic interaction of HDAC1 with a glucocorticoid receptor-regulated gene is modulated by the activity state of the promoter. J Biol Chem. 2011 Mar 4;286(9):7641-7.
REF 10 The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): tissue levels, mechanism of action, and potential physiologic role. Mol Med. 1996 Sep;2(5):597-607.
REF 11 Delimitation of two regions in the 90-kDa heat shock protein (Hsp90) able to interact with the glucocorticosteroid receptor (GR). Exp Cell Res. 1999 Mar 15;247(2):461-74.
REF 12 Proteome-scale Binary Interactomics in Human Cells. Mol Cell Proteomics. 2016 Dec;15(12):3624-3639.
REF 13 A comprehensive resource of interacting protein regions for refining human transcription factor networks. PLoS One. 2010 Feb 24;5(2):e9289.
REF 14 Ligand-specific glucocorticoid receptor activation in human platelets. Blood. 2005 Dec 15;106(13):4167-75.
REF 15 Overexpression, characterization, and purification of a recombinant mouse immunophilin FKBP-52 and identification of an associated phosphoprotein. Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6839-43.
REF 16 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 17 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 18 An additional region of coactivator GRIP1 required for interaction with the hormone-binding domains of a subset of nuclear receptors. J Biol Chem. 1999 Feb 5;274(6):3496-502.
REF 19 RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding. J Biol Chem. 2002 Jul 19;277(29):26238-43.
REF 20 Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: the role of tyrosine 735. Mol Endocrinol. 2003 May;17(5):845-59.
REF 21 STAT3 acts as a co-activator of glucocorticoid receptor signaling. J Biol Chem. 1997 Dec 5;272(49):30607-10.
REF 22 STAT3-dependent enhanceosome assembly and disassembly: synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene. Genes Dev. 2003 Oct 15;17(20):2564-77.
REF 23 Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors. Biochemistry. 1998 Jun 30;37(26):9586-94.
REF 24 Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J Exp Med. 2006 Jan 23;203(1):7-13.
REF 25 Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors. Mol Cell Biol. 1995 Feb;15(2):943-53.
REF 26 Recruitment of octamer transcription factors to DNA by glucocorticoid receptor. Mol Cell Biol. 1998 Jun;18(6):3416-30.
REF 27 Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding. Mol Cell Biol. 1999 Oct;19(10):7106-22.
REF 28 Stabilization of the unliganded glucocorticoid receptor by TSG101. J Biol Chem. 2005 Mar 25;280(12):11120-6.
REF 29 Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. EMBO J. 1999 Oct 1;18(19):5380-8.
REF 30 Interaction of mitochondrial thioredoxin with glucocorticoid receptor and NF-kappaB modulates glucocorticoid receptor and NF-kappaB signalling in HEK-293 cells. Biochem J. 2009 Aug 27;422(3):521-31.
REF 31 Direct association with thioredoxin allows redox regulation of glucocorticoid receptor function. J Biol Chem. 1999 Jan 29;274(5):3182-8.
REF 32 Role of BCL2-associated athanogene 1 in differential sensitivity of human endothelial cells to glucocorticoids. Arterioscler Thromb Vasc Biol. 2013 May;33(5):1046-55.
REF 33 RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis. J Biol Chem. 1998 Jun 5;273(23):14620-5.
REF 34 Regulation of subnuclear localization is associated with a mechanism for nuclear receptor corepression by RIP140. Mol Cell Biol. 2003 Jun;23(12):4187-98.
REF 35 An atlas of combinatorial transcriptional regulation in mouse and man. Cell. 2010 Mar 5;140(5):744-52.
REF 36 DAXX, FLASH, and FAF-1 modulate mineralocorticoid and glucocorticoid receptor-mediated transcription in hippocampal cells--toward a basis for the opposite actions elicited by two nuclear receptors Mol Pharmacol. 2004 Mar;65(3):761-9.
REF 37 Promyelocytic leukemia protein (PML) functions as a glucocorticoid receptor co-activator by sequestering Daxx to the PML oncogenic domains (PODs) to enhance its transactivation potential. J Biol Chem. 2003 May 2;278(18):15958-65.

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