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| Target General Information |
Top |
| Target ID |
T39977 |
Target Info
|
| Target Name |
Macrophage migration inhibitory factor (MIF) |
| Synonyms |
Phenylpyruvate tautomerase; MMIF; L-dopachrome tautomerase; L-dopachrome isomerase; Glycosylation-inhibiting factor; GLIF; GIF |
| Target Type |
Clinical trial Target |
| Gene Name |
MIF |
| Biochemical Class |
Intramolecular oxidoreductase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Peptidases |
[+] 1 Peptidases |
+ |
| Interacting Target Name |
JUN activation domain binding protein (COPS5) |
Literature-reported Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Signalosome subunit 5; SGN5; Jun activation domain-binding protein 1; JAB1; CSN5; COP9 signalosome complex subunit 5 |
| Evidence Score (E-score) |
4 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Reconstituted Complex |
[2] |
| 4 |
Yeast two hybrid |
[1] |
| References |
Top |
| REF 1 |
Binding of JAB1/CSN5 to MIF is mediated by the MPN domain but is independent of the JAMM motif. FEBS Lett. 2005 Mar 14;579(7):1693-701.
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| REF 2 |
Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1. Nature. 2000 Nov 9;408(6809):211-6.
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