Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T38301 Target Info
Target Name Ribonucleoside-diphosphate reductase M2 (RRM2)
Synonyms Ribonucleotide reductase small subunit; Ribonucleotide reductase small chain; Ribonucleoside-diphosphate reductase subunit M2; RR2
Target Type Successful Target
Gene Name RRM2
Biochemical Class CH/CH(2) oxidoreductase
UniProt ID
RIR2_HUMAN 
Target Interacting Proteins  Top
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Protein Name Ribonucleoside-diphosphate reductase subunit M1 (RRM1) Interacting Protein Interacting Protein Info
UniProt ID
RIR1_HUMAN 
Synonyms RR1; Ribonucleotide reductase large subunit; Ribonucleoside-diphosphate reductase subunit M1; Ribonucleoside-diphosphate reductase large subunit
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Co-fractionation [3]
4 Reconstituted Complex [4]
5 Yeast two hybrid [5]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53. Cancer Res. 2003 Oct 15;63(20):6583-94.
REF 3 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 4 A comprehensive model for the allosteric regulation of mammalian ribonucleotide reductase. Functional consequences of ATP- and dATP-induced oligomerization of the large subunit. Biochemistry. 2002 Jan 15;41(2):462-74.
REF 5 Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase. Genes Dev. 2010 Feb 15;24(4):333-8.

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