Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T34234 Target Info
Target Name Vitamin D3 receptor (VDR)
Synonyms Vitamin D(3) receptor; Nuclear vitamin D receptor; Nuclear receptor subfamily 1 group I member 1; NR1I1; 1,25-dihydroxyvitamin D3 receptor
Target Type Successful Target
Gene Name VDR
Biochemical Class Nuclear hormone receptor
UniProt ID
VDR_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 9 Experimental Evidences +
1 Reconstituted Complex [1]
2 Reconstituted Complex [2]
3 Reconstituted Complex [3]
4 Reconstituted Complex [4]
5 Reconstituted Complex [5]
6 Reconstituted Complex [6]
7 Yeast two hybrid [7]
8 Yeast two hybrid [8]
9 Yeast two hybrid [9]
Interacting Target Name Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA3_HUMAN 
Synonyms TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Co-localization [11]
3 Reconstituted Complex [12]
4 Yeast two hybrid [13]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC) Interacting Protein Interacting Protein Info
UniProt ID
PP1G_HUMAN 
Synonyms PP.1G; PP1C; PPP1G
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Affinity Capture-Western [14]
3 Reconstituted Complex [14]
4 Yeast two hybrid [14]
Kinases [+] 1 Kinases +
Interacting Target Name Proto-oncogene c-Src (SRC) Successful Target Interacting Protein Info
UniProt ID
SRC_HUMAN 
Synonyms Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Co-localization [16]
3 Reconstituted Complex [17]
4 Yeast two hybrid [13]
5 Yeast two hybrid [18]
Mediator complexes [+] 3 Mediator complexes +
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 1 (MED1) Interacting Protein Interacting Protein Info
UniProt ID
MED1_HUMAN 
Synonyms CRSP1; CRSP200; DRIP205; DRIP230; PBP; PPARBP; PPARGBP; RB18A; TRAP220; TRIP2
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [19]
2 Affinity Capture-MS [20]
3 Co-localization [16]
4 Co-localization [11]
5 Reconstituted Complex [5]
6 Reconstituted Complex [20]
7 Yeast two hybrid [7]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 12 (MED12) Interacting Protein Interacting Protein Info
UniProt ID
MED12_HUMAN 
Synonyms ARC240; CAGH45; FGS1; HOPA; MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [19]
2 Affinity Capture-MS [20]
3 Reconstituted Complex [20]
Interacting Protein Name Mediator of RNA polymerase II transcription subunit 14 (MED14) Interacting Protein Interacting Protein Info
UniProt ID
MED14_HUMAN 
Synonyms CRSP150; CRSP2; CSRP; CXorf4; DRIP150; EXLM1; RGR1; TRAP170
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [19]
2 Affinity Capture-MS [20]
3 Reconstituted Complex [20]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Retinoic acid receptor RXR-alpha (RXRA) Successful Target Interacting Protein Info
UniProt ID
RXRA_HUMAN 
Synonyms RXRalpha; Retinoid X receptor alpha; Nuclear receptor subfamily 2 group B member 1; NR2B1
Evidence Score (E-score) 19 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Affinity Capture-Western [22]
3 Co-localization [23]
4 Co-localization [24]
5 Co-localization [25]
6 Reconstituted Complex [26]
7 Reconstituted Complex [12]
8 Reconstituted Complex [4]
9 Reconstituted Complex [5]
10 Reconstituted Complex [6]
11 Reconstituted Complex [27]
12 Reconstituted Complex [22]
13 Reconstituted Complex [25]
14 Reconstituted Complex [28]
15 Reconstituted Complex [29]
16 Reconstituted Complex [30]
17 Yeast two hybrid [31]
18 Yeast two hybrid [9]
19 Yeast two hybrid [32]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Protein Name Lysine-specific demethylase hairless (HR) Interacting Protein Interacting Protein Info
UniProt ID
HAIR_HUMAN 
Synonyms ALUNC; AU; HSA277165; HYPT4; MUHH; MUHH1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [33]
2 Reconstituted Complex [34]
3 Reconstituted Complex [33]
Transcription regulators [+] 2 Transcription regulators +
Interacting Protein Name Nuclear receptor coactivator 2 (NCOA2) Interacting Protein Interacting Protein Info
UniProt ID
NCOA2_HUMAN 
Synonyms GRIP1; KAT13C; NCoA.2; SRC2; TIF2; bHLHe75
Evidence Score (E-score) 4 Experimental Evidences +
1 Reconstituted Complex [27]
2 Yeast two hybrid [35]
3 Yeast two hybrid [13]
4 Yeast two hybrid [18]
Interacting Protein Name Nuclear receptor corepressor 1 (NCOR1) Interacting Protein Interacting Protein Info
UniProt ID
NCOR1_HUMAN 
Synonyms N.CoR; N.CoR1; PPP1R109; TRAC1; hN.CoR
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [36]
2 Reconstituted Complex [3]
3 Yeast two hybrid [37]
Other proteins [+] 1 Other proteins +
Interacting Protein Name SNW domain-containing protein 1 (SNW1) Interacting Protein Interacting Protein Info
UniProt ID
SNW1_HUMAN 
Synonyms Bx42; NCOA.62; PRPF45; Prp45; SKIIP; SKIP
Evidence Score (E-score) 3 Experimental Evidences +
1 Reconstituted Complex [26]
2 Reconstituted Complex [27]
3 Yeast two hybrid [26]
References  Top
REF 1 The unique tryptophan residue of the vitamin D receptor is critical for ligand binding and transcriptional activation. J Bone Miner Res. 2001 Jan;16(1):39-45.
REF 2 Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors. Mol Cell Biol. 1997 Apr;17(4):2166-76.
REF 3 Agonist-triggered modulation of the activated and silent state of the vitamin D(3) receptor by interaction with co-repressors and co-activators. J Mol Biol. 2000 Dec 15;304(5):793-801.
REF 4 Regulation of ligand-induced heterodimerization and coactivator interaction by the activation function-2 domain of the vitamin D receptor. Mol Endocrinol. 2000 Nov;14(11):1776-87.
REF 5 1alpha,25-dihydroxy vitamin D3-enhanced expression of the osteocalcin gene involves increased promoter occupancy of basal transcription regulators and gradual recruitment of the 1alpha,25-dihydroxy vitamin D3 receptor-SRC-1 coactivator complex. J Cell Physiol. 2008 Mar;214(3):740-9.
REF 6 Lysine 246 of the vitamin D receptor is crucial for ligand-dependent interaction with coactivators and transcriptional activity. J Biol Chem. 1999 May 7;274(19):13503-10.
REF 7 2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 potently stimulates gene-specific DNA binding of the vitamin D receptor in osteoblasts. J Biol Chem. 2003 Aug 22;278(34):31756-65.
REF 8 A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors. Nucleic Acids Res. 2013 Nov;41(21):9663-79.
REF 9 Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13.
REF 10 Stimulation of Sirt1-regulated FoxO protein function by the ligand-bound vitamin D receptor. Mol Cell Biol. 2010 Oct;30(20):4890-900.
REF 11 Spatio-temporal activation of chromatin on the human CYP24 gene promoter in the presence of 1alpha,25-Dihydroxyvitamin D3. J Mol Biol. 2005 Jul 1;350(1):65-77.
REF 12 Structural determinants of the agonist-independent association of human peroxisome proliferator-activated receptors with coactivators. J Biol Chem. 2005 Jul 15;280(28):26543-56.
REF 13 Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation. Mol Endocrinol. 2003 Nov;17(11):2320-8.
REF 14 A vitamin D receptor-Ser/Thr phosphatase-p70 S6 kinase complex and modulation of its enzymatic activities by the ligand. J Biol Chem. 2002 Jul 12;277(28):24847-50.
REF 15 A novel bile acid-activated vitamin D receptor signaling in human hepatocytes. Mol Endocrinol. 2010 Jun;24(6):1151-64.
REF 16 Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor. Nucleic Acids Res. 2006 Jan 24;34(2):543-54.
REF 17 Dynamic and ligand-selective interactions of vitamin D receptor with retinoid X receptor and cofactors in living cells. Mol Pharmacol. 2011 Dec;80(6):1147-55.
REF 18 Calmodulin-dependent kinase IV stimulates vitamin D receptor-mediated transcription. Mol Endocrinol. 2005 Sep;19(9):2309-19.
REF 19 Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol Cell. 1999 Mar;3(3):361-70.
REF 20 Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature. 1999 Apr 29;398(6730):824-8.
REF 21 AF4 and AF4-MLL mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3. Oncotarget. 2015 Sep 22;6(28):25784-800.
REF 22 p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer. Cancer Cell. 2016 Oct 10;30(4):595-609.
REF 23 The human peroxisome proliferator-activated receptor delta gene is a primary target of 1alpha,25-dihydroxyvitamin D3 and its nuclear receptor. J Mol Biol. 2005 Jun 3;349(2):248-60.
REF 24 1,25-Dihydroxyvitamin D3 stimulates cyclic vitamin D receptor/retinoid X receptor DNA-binding, co-activator recruitment, and histone acetylation in intact osteoblasts. J Bone Miner Res. 2005 Feb;20(2):305-17.
REF 25 Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene. Biochim Biophys Acta. 2007 Jul;1771(7):864-72.
REF 26 Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription. J Biol Chem. 1998 Jun 26;273(26):16434-41.
REF 27 Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription. J Biol Chem. 2001 Nov 2;276(44):40614-20.
REF 28 Androgen-receptor coregulators mediate the suppressive effect of androgen signals on vitamin D receptor activity. Endocrine. 2005 Feb;26(1):1-9.
REF 29 A 5'-distal enhanceosome in the PDGF-A gene is activated in choriocarcinoma cells via ligand-independent binding of vitamin D receptor and constitutive jun kinase signaling. Oncogene. 2005 Apr 14;24(16):2654-66.
REF 30 Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site. Biochim Biophys Acta. 2006 Jul;1761(7):686-97.
REF 31 Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators. Science. 1999 Feb 26;283(5406):1317-21.
REF 32 Curcumin: a novel nutritionally derived ligand of the vitamin D receptor with implications for colon cancer chemoprevention. J Nutr Biochem. 2010 Dec;21(12):1153-61.
REF 33 Physical and functional interaction between the vitamin D receptor and hairless corepressor, two proteins required for hair cycling. J Biol Chem. 2003 Oct 3;278(40):38665-74.
REF 34 Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle. J Cell Biochem. 2010 Jun 1;110(3):671-86.
REF 35 Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs. Mol Cell Biol. 2003 Mar;23(6):2135-50.
REF 36 Involvement of SMRT corepressor in transcriptional repression by the vitamin D receptor. Mol Endocrinol. 2009 Feb;23(2):251-64.
REF 37 VDR-Alien: a novel, DNA-selective vitamin D(3) receptor-corepressor partnership. FASEB J. 2000 Jul;14(10):1455-63.

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