Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T31186 Target Info
Target Name Eukaryotic initiation factor 4E (EIF4E)
Synonyms eIF4F 25 kDa subunit; eIF4E; eIF-4F 25 kDa subunit; eIF-4E; Eukaryotic translation initiation factor 4E; EIF4F; EIF4EL1
Target Type Literature-reported Target
Gene Name EIF4E
UniProt ID
IF4E_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Eukaryotic initiation factor 4A-I (EIF4A1) Interacting Protein Interacting Protein Info
UniProt ID
IF4A1_HUMAN 
Synonyms DDX2A; EIF.4A; EIF4A; eIF.4A.I; eIF4A.I
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Eukaryotic initiation factors [+] 4 Eukaryotic initiation factors +
Interacting Target Name Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) Literature-reported Target Interacting Protein Info
UniProt ID
4EBP1_HUMAN 
Synonyms Phosphorylated heat- andacid-stable protein regulated by insulin 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I; eIF4E-binding protein 1; 4E-BP1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
3 Co-fractionation [4]
4 Co-purification [5]
5 Reconstituted Complex [6]
6 Yeast two hybrid [7]
Interacting Protein Name Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) Interacting Protein Interacting Protein Info
UniProt ID
IF4G1_HUMAN 
Synonyms EIF.4G1; EIF4F; EIF4G; EIF4GI; P220; PARK18
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [8]
3 Co-fractionation [4]
4 Far Western [6]
5 Reconstituted Complex [9]
Interacting Protein Name Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) Interacting Protein Interacting Protein Info
UniProt ID
4EBP2_HUMAN 
Synonyms Eukaryotic translation initiation factor 4E-binding protein 2; eIF4E-binding protein 2; 4E-BP2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [10]
3 Reconstituted Complex [6]
4 Yeast two hybrid [7]
Interacting Protein Name Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3) Interacting Protein Interacting Protein Info
UniProt ID
IF4G3_HUMAN 
Synonyms eIF.4G 3; eIF4G 3; eIF4GII
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [4]
3 Far Western [11]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Eukaryotic translation initiation factor 4E transporter (EIF4ENIF1) Interacting Protein Interacting Protein Info
UniProt ID
4ET_HUMAN 
Synonyms 4E.T; Clast4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [9]
3 Yeast two hybrid [12]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Mol Cell Biol. 2006 May;26(10):3955-65.
REF 3 Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase. J Biol Chem. 2000 Apr 14;275(15):10779-87.
REF 4 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 5 Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors. Eur J Biochem. 2002 Jun;269(12):3076-85.
REF 6 The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Mol Cell Biol. 1995 Sep;15(9):4990-7.
REF 7 Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Nat Commun. 2014 Apr 11;5:3650.
REF 8 Amino acid-induced stimulation of translation initiation in rat skeletal muscle. Am J Physiol. 1999 Dec;277(6):E1077-86.
REF 9 Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches. PLoS One. 2015 Apr 29;10(4):e0123352.
REF 10 Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. Mol Cell. 2010 Mar 26;37(6):797-808.
REF 11 A novel functional human eukaryotic translation initiation factor 4G. Mol Cell Biol. 1998 Jan;18(1):334-42.
REF 12 An empirical framework for binary interactome mapping. Nat Methods. 2009 Jan;6(1):83-90.

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