Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T30502 Target Info
Target Name DNA replication licensing factor MCM6 (MCM6)
Synonyms p105MCM; Minichromosome maintenanceprotein 6
Target Type Literature-reported Target
Gene Name MCM6
Biochemical Class Acid anhydride hydrolase
UniProt ID
MCM6_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 5 Acid anhydride hydrolases +
Interacting Target Name DNA replication licensing factor MCM7 (MCM7) Literature-reported Target Interacting Protein Info
UniProt ID
MCM7_HUMAN 
Synonyms P1.1-MCM3; Minichromosome maintenanceprotein 7; MCM2; CDC47 homolog; CDC47
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Co-fractionation [4]
5 Co-fractionation [5]
6 Reconstituted Complex [6]
7 Yeast two hybrid [7]
Interacting Protein Name DNA replication licensing factor MCM2 (MCM2) Interacting Protein Interacting Protein Info
UniProt ID
MCM2_HUMAN 
Synonyms BM28; CCNL1; CDCL1; D3S3194; MITOTIN; cdc19
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-MS [1]
3 Affinity Capture-Western [2]
4 Reconstituted Complex [6]
5 Yeast two hybrid [7]
Interacting Protein Name DNA replication licensing factor MCM4 (MCM4) Interacting Protein Interacting Protein Info
UniProt ID
MCM4_HUMAN 
Synonyms CDC21; CDC54; NKCD; NKGCD; P1.CDC21; hCdc21
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-MS [1]
3 Affinity Capture-Western [2]
4 Yeast two hybrid [7]
Interacting Protein Name DNA replication licensing factor MCM3 (MCM3) Interacting Protein Interacting Protein Info
UniProt ID
MCM3_HUMAN 
Synonyms HCC5; P1.MCM3; P1.h; RLFB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [9]
3 Co-fractionation [4]
Interacting Protein Name Structural maintenance of chromosomes protein 1A (SMC1A) Interacting Protein Interacting Protein Info
UniProt ID
SMC1A_HUMAN 
Synonyms CDLS2; DXS423E; SB1.8; SMC1; SMC1L1; SMC1alpha; SMCB
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Affinity Capture-Western [3]
Other proteins [+] 4 Other proteins +
Interacting Protein Name Protein MCM10 homolog (MCM10) Interacting Protein Interacting Protein Info
UniProt ID
MCM10_HUMAN 
Synonyms CNA43; DNA43
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [10]
3 Yeast two hybrid [11]
4 Yeast two hybrid [12]
Interacting Target Name Facilitates chromatin transcription complex (FACT) Clinical trial Target Interacting Protein Info
UniProt ID
SSRP1_HUMAN 
Synonyms T160; Structure-specific recognition protein 1; Recombination signal sequence recognition protein 1; hSSRP1; FACTp80; FACT80; FACT complex subunit SSRP1; FACT 80 kDa subunit; Facilitates chromatin transcription complex subunit SSRP1; Facilitates chromatin transcription complex 80 kDa subunit; Chromatin-specific transcription elongation factor 80 kDa subunit
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [13]
2 Affinity Capture-Western [14]
Interacting Protein Name Mini-chromosome maintenance complex-binding protein (MCMBP) Interacting Protein Interacting Protein Info
UniProt ID
MCMBP_HUMAN 
Synonyms C10orf119; MCM.BP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [4]
Interacting Protein Name Splicing factor 3A subunit 1 (SF3A1) Interacting Protein Interacting Protein Info
UniProt ID
SF3A1_HUMAN 
Synonyms PRP21; PRPF21; SAP114; SF3A120
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [8]
2 Co-fractionation [5]
References  Top
REF 1 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 2 Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex. J Biol Chem. 2002 Nov 8;277(45):42471-9.
REF 3 Direct interaction between cohesin complex and DNA replication machinery. Biochem Biophys Res Commun. 2006 Mar 17;341(3):770-5.
REF 4 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 5 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 6 Mammalian Mcm2/4/6/7 complex forms a toroidal structure. Genes Cells. 2003 May;8(5):413-21.
REF 7 Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells. J Mol Biol. 2003 Mar 14;327(1):111-28.
REF 8 An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. Nat Commun. 2016 May 13;7:11491.
REF 9 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 10 Self-assembling protein microarrays. Science. 2004 Jul 2;305(5680):86-90.
REF 11 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.
REF 12 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 13 A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell. 2010 Nov 24;40(4):645-57.
REF 14 Functional cooperation between FACT and MCM helicase facilitates initiation of chromatin DNA replication. EMBO J. 2006 Sep 6;25(17):3975-85.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.